Aromatic constituents of Uvaria grandiflora

Journal of Natural Products
Sridevi AnkisettyLarry Walker

Abstract

Grandiuvarone A (1) and grandiuvarins A-C (2-4) were isolated from the bark of Uvaria grandiflora. The structures of these new aromatic compounds were elucidated on the basis of spectroscopic analyses, especially 2D NMR techniques. Only compound 1 exhibited antileishmanial activity, with IC(50)/IC(90) values of 0.7/1.5 microg/mL. The positive controls pentamidine and amphotericin B had IC(50)/IC(90) values of 1.6/6.6 and 0.17/0.34 microg/mL, respectively.

References


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Citations

Oct 31, 2009·Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials·Ru-Mei LuJian-Hua Wei
Mar 8, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Rongxiang ChenXiaobing Wan
May 30, 2019·Natural Product Reports·Attila Mándi, Tibor Kurtán
Sep 26, 2014·Chemical Reviews·Hidayat HussainSimon Gibbons
Nov 6, 2014·Journal of Natural Products·Allan Patrick G MacabeoScott G Franzblau
Nov 28, 2017·Journal of Natural Products·Allan Patrick G MacabeoMary J Garson
Mar 6, 2019·Journal of Natural Products·Pornphimol MeesakulSurat Laphookhieo
Nov 5, 2014·Chemical Reviews·Advait S NagleValentina Molteni

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