Aromatic Fluorination of Multiblock Amphiphile Enhances Its Incorporation into Lipid Bilayer Membranes.

ChemistryOpen
Ryo SasakiKazushi Kinbara

Abstract

We designed multiblock amphiphiles AmF and AmH, which consist of perfluorinated and non-fluorinated hydrophobic units, respectively. Absorption spectroscopy revealed that both amphiphiles are molecularly dispersed in organic solvent, while they form aggregates under aqueous conditions. Furthermore, we investigated whether AmF and AmH can be incorporated into DOPC lipid bilayer membranes, and found that the maximum concentration of AmF that can be incorporated into DOPC lipid bilayer membranes is 43 times higher than that of AmH.

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Citations

Dec 29, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Briana R SchrageChristopher J Ziegler
Apr 29, 2021·Chemical Communications : Chem Comm·Yusuke ShimizuKazushi Kinbara
Jan 15, 2021·Journal of the American Chemical Society·Ryo SasakiKazushi Kinbara
Sep 10, 2021·Accounts of Chemical Research·Kohei SatoKazushi Kinbara

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Methods Mentioned

BETA
dynamic light scattering
fluorescence microscopy
dynamic light scatterings

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