PMID: 8958145Jan 1, 1997Paper

Aromatic hydroxylation in nasal lavage fluid following ambient ozone exposure

Free Radical Biology & Medicine
T M FrischerG Lubec

Abstract

Ozone at ambient concentrations affects lung function and initiates an inflammatory response of the airways. However, the underlying mechanisms are poorly understood. In vitro studies have shown that ozone reacts with water to give reactive hydroxyl radicals capable of oxidizing a wide range of biomolecules. We conducted a study to determine if in vivo hydroxyl radical attack on human airways occurs under natural exposure to ozone. The relation of orthotyrosine to para-tyrosine as a measure of hydroxyl radical attack was analyzed in nasal lavage samples of 44 primary school children in an epidemiologic study. Repeated nasal lavages were performed between May and October 1991 both following "low" (daily half-hour maximum < 140 micrograms/m3, approximately 70 ppb) and "high" (daily half-hour maximum > 180 micrograms/m3, approximately 90 ppb) ozone exposure. Concomitantly, lung function tests were performed. On average, 11.6 (6-16) nasal lavages were performed for each of 24 study days (10 days following "low" ozone exposure and 14 days following "high" ozone exposure). Average ortho-tyrosine (median; 5-95% percentile) for each child was 0.037 mumol/L (0.016-0.064 mumol/L) and average para-tyrosine was 15.7 mumol/L (9.8-24.1 mumol...Continue Reading

References

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Citations

Apr 3, 2012·Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India·Adin SelcukCandan Ozogul
Dec 4, 2003·Biochimie·Yong-Ki LeeSanghwa Han
Nov 30, 1999·International Journal of Pediatric Otorhinolaryngology·J FajstavrJ Fiala
Nov 9, 2000·Archives of Medical Research·J Mochca-Morales
Feb 28, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Terry L NoahFrederick W Henderson
Aug 3, 1999·American Journal of Respiratory and Critical Care Medicine·T FrischerR Urbanek
Aug 10, 2000·American Journal of Respiratory and Critical Care Medicine·T Frischer, E Baraldi
May 17, 2008·American Journal of Respiratory Cell and Molecular Biology·Catherine M McDougallGarry M Walsh
Apr 10, 2008·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Florian SingerThomas Frischer
Apr 5, 2016·Ageing Research Reviews·Brett R Ipson, Alfred L Fisher
Jan 1, 2014·Korean Journal for Food Science of Animal Resources·Youngjae ChoSung Ki Lee
Jan 22, 2015·Journal of Exposure Science & Environmental Epidemiology·Jaime Mirowsky, Terry Gordon
Nov 7, 1998·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·B LubecG Lubec

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