PMID: 107839Apr 1, 1979

Aromatic substrate specificity of browning by cultures of the Legionnaires' disease bacterium

Annals of Internal Medicine
W B Baine, J K Rasheed

Abstract

When the Legionnaires' disease (LD) bacterium is grown on supplemented Mueller-Hinton agar, brown pigmentation of the medium occurs. Since this browning may result from tyrosinase-mediated formation of melanin, we supplemented yeast-extract agar with various aromatic precursors of melanin and inoculated it with eight strains of the LD bacterium. Browning occurred with growth of each LD strain of the bacterium on yeast-extract agar enriched with 2.5 mmol/L of L-phenylalanine or L-tyrosine but not without such enrichment. Equimolar D-phenylalanine or D-tryosine in yeast-extract agar did not enhance browning. The LD bacterium may possess L-phenylalanine hydroxylase activity, but it does not use D-aromatic amino acids effectively in pigment production.

Citations

Jun 6, 2007·Infection and Immunity·Christa H Chatfield, N P Cianciotto
Dec 1, 1985·Zentralblatt Für Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology·H E Müller
Oct 13, 2015·Journal of Medicinal Chemistry·Oscar AubiJarl Underhaug

Related Concepts

Agar
Legionnaires' Disease
Phaeomelanins
Endorphenyl
Phenylalanine Hydroxylase
Pigments, Biological
Phenoloxidase B
Tyrosine

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