Aromatic-turmerone ameliorates imiquimod-induced psoriasis-like inflammation of BALB/c mice

International Immunopharmacology
Yong-Liang LiHuixiong Chen

Abstract

Psoriasis is a usual immune-mediated inflammatory skin disease with undefined pathogenesis. Aromatic-turmerone (ATM) is a mainly constituent of essential oil from Curcuma longa L. It has been shown to exhibit strong anti-oxidant, anti-tumor activities and anti-inflammatory effects. In this study, we investigated the effects of ATM on imiquimod (IMQ)-induced psoriasis-like BALB/c mice and its molecular mechanisms for anti-inflammatory effect. ATM showed inhibition of the transfer of CD8+ T cells in epidermis, and reduced expression of NF-κB and COX-2 as well as phosphorylation of p38 MAPK. It also decreased the level of TNF-α and IL-6, and down-regulates IL-17 IL-22 and IL-23 mRNA synthesis. Notably, we demonstrated that topically applied ATM alleviated skin inflammation in IMQ-induced mice. These results indicate that ATM, a natural active compound exhibits anti-inflammatory activity and is a promising candidate molecule to treat inflammatory skin diseases, such as psoriasis.

Citations

Feb 29, 2020·Expert Opinion on Drug Discovery·Li-Ming ZhouGuang-Fu Yang
Oct 25, 2020·Journal of Cosmetic Dermatology·Bingying WangHaji Aker Aisa
Jan 1, 2021·Plants·María Dolores Ibáñez, María Amparo Blázquez
Feb 20, 2021·Life Sciences·Ajaikumar B KunnumakkaraBharat B Aggarwal
Jul 22, 2021·Drug Delivery and Translational Research·Zhiyue ZhaoNan Li

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