Aromaticity/Bulkiness of Surface Ligands to Promote the Interaction of Anionic Amphiphilic Gold Nanoparticles with Lipid Bilayers

Langmuir : the ACS Journal of Surfaces and Colloids
Jinhong GaoYibing Zhao

Abstract

The presence of large hydrophobic aromatic residues in cell-penetrating peptides or proteins has been demonstrated to be advantageous for their cell penetration. This phenomenon has also been observed when AuNPs were modified with peptides containing aromatic amino acids. However, it is still not clear how the presence of hydrophobic and aromatic groups on the surface of anionic AuNPs affects their interaction with lipid bilayers. Here, we studied the interaction of a range of anionic amphiphilic AuNPs coated by different combinations of hydrophobic and anionic ligands with four different types of synthetic lipid vesicles. Our results demonstrated the important role of the surface aromatic or bulky groups, relative to the hydrocarbon chains, in the interaction of anionic AuNPs with lipid bilayers. Hydrophobic interaction itself arising from the insertion of aromatic/bulky ligands on the surface of AuNPs into lipid bilayers is sufficiently strong to cause overt disruption of lipid vesicles and cell membranes. Moreover, by comparing the results obtained from AuNPs coated with aromatic ligands and cyclohexyl ligands lacking aromaticity respectively, we demonstrated that the bulkiness of the terminal groups in hydrophobic ligands i...Continue Reading

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Citations

Jun 29, 2017·ACS Applied Materials & Interfaces·Fangfang LiLichen Yin
Oct 28, 2020·Proceedings of the National Academy of Sciences of the United States of America·Isabel U Foreman-OrtizJoel A Pedersen
Sep 22, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·Kwahun Lee, Yan Yu
Jan 3, 2019·Langmuir : the ACS Journal of Surfaces and Colloids·Nishu KanwaAnjan Chakraborty
Nov 18, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Mina R NarouzCathleen M Crudden
Dec 5, 2017·The Journal of Physical Chemistry. B·Qing Shao, Carol K Hall

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