Aronia (Aronia melanocarpa) Polyphenols Modulate the Microbial Community in a Simulator of the Human Intestinal Microbial Ecosystem (SHIME) and Decrease Secretion of Proinflammatory Markers in a Caco-2/endothelial Cell Coculture Model

Molecular Nutrition & Food Research
Ting WuJohn Van Camp

Abstract

To explore the mechanisms behind the health effects of Aronia (Aronia melanocarpa), the microbial community modulating and anti-inflammatory effects of Aronia polyphenols are investigated by combining the similutor of the human intestinal microbial ecosystem (SHIME) with a coculture of intestinal and endothelial cells. Administration of Aronia juice (6.5g L-1 ) to the SHIME for 2 weeks increases the abundance of firmicutes to 92% in the ascending colon (AC), 85% in the transverse colon (TC), and 82% in the descending colon (DC; p < 0.001), proteobacteria (6.7% in AC, p < 0.001), and Akkermansia (14% in TC and 18% in DC, p < 0.001) and decreases the abundance of Bifidobacterium species, associated with a decrease of acetate and increase of propionate and butyrate, whereas no significant difference is observed upon placebo juice treatment. After addition of the digests to TNF-α challenged Caco-2/endothelial cocultures, intercellular adhesion molecule (ICAM)-1, IL-8, and monocyte chemoattractant protein-1 levels are significantly downregulated. Interestingly, Aronia juice treats digests from each colon compartment resulting in a stronger decrease of the ICAM-1 secretion (up to 73%, p < 0.001) compared to their corresponding placeb...Continue Reading

References

Jul 10, 1998·Veterinary Immunology and Immunopathology·J Schwager, J Schulze
Jun 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anthony R SmithTory M Hagen
Sep 3, 2002·Biochimica Et Biophysica Acta·Roser RoigM Josepa Salvadó
Aug 5, 2003·Carcinogenesis·Miriam Nannette EbertBeatrice Louise Pool-Zobel
Oct 7, 2004·Applied and Environmental Microbiology·Sylvia H DuncanHarry J Flint
Dec 30, 2004·Investigative Ophthalmology & Visual Science·Kazuhiro OhgamiShigeaki Ohno
Feb 14, 2006·Toxicology in Vitro : an International Journal Published in Association with BIBRA·José Moisés LaparraRosaura Farré
Dec 18, 2007·Applied and Environmental Microbiology·Muriel DerrienWillem M de Vos
Feb 12, 2010·FEMS Microbiology Letters·Giuseppina MandalariMartin S J Wickham
May 11, 2010·International Journal of Food Microbiology·Dobroslawa BialonskaDaneel Ferreira
Feb 5, 2011·Molecular Nutrition & Food Research·Vincenzo FoglianoGlenn Gibson
Apr 5, 2011·Journal of Applied Microbiology·M KutscheraA Braune
Jun 1, 2012·Journal of Agricultural and Food Chemistry·Fernando Sánchez-PatánBegoña Bartolomé
Aug 1, 2013·Molecular Nutrition & Food Research·Antonio SpecialeFrancesco Cimino
Jan 15, 2015·Journal of Laboratory Automation·Balaji SrinivasanJames J Hickman
Mar 5, 2016·British Journal of Clinical Pharmacology·Marialaura BonaccioUNKNOWN MOLI-SANI Study Investigators
Mar 11, 2016·Gut Microbes·Annett Braune, Michael Blaut
Apr 16, 2016·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M J AmiotA Vinet
Oct 21, 2016·Redox Biology·Gobinath ShanmugamNamakkal Soorappan Rajasekaran
Feb 6, 2017·International Journal of Food Sciences and Nutrition·Nevena KardumMaria Glibetić
Jun 16, 2017·Environmental Microbiology·Kim De PaepeTom Van de Wiele

❮ Previous
Next ❯

Citations

Mar 28, 2020·Critical Reviews in Food Science and Nutrition·Amar D E Van LaarJohn Van Camp
Aug 21, 2019·Current Opinion in Pharmacology·Jorge F Vázquez-CastellanosJeroen Raes
May 7, 2021·Food Chemistry·Xiaocao LiuBradley W Bolling
Jun 11, 2021·Frontiers in Nutrition·Suman Kumar Ray, Sukhes Mukherjee
Aug 17, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Tolulope Joshua Ashaolu
Apr 6, 2020·Food Research International·Iramaia Angelica Neri-Numa, Glaucia Maria Pastore

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here