Abstract
Despite a low risk of liver failure and preserved liver function, non-cirrhotic hepatocellular carcinoma (HCC) has a poor prognosis. In the current study, we evaluated an active regulator of SIRT1 (AROS) as a prognostic biomarker in non-cirrhotic HCC. mRNA levels of AROS were measured in tumor and non-tumor tissues obtained from 283 non-cirrhotic HCC patients. AROS expression was exclusively up-regulated in recurrent tissues from the non-cirrhotic HCC patients (P = 0.015) and also in tumor tissues irrespective of tumor stage (P < 0.001) or BCLC stage (P < 0.001). High mRNA levels of AROS were statistically significantly associated with tumor stage (P < 0.001), BCLC stage (P = 0.007), alpha fetoprotein (AFP) level (P = 0.013), microvascular invasion (P = 0.001), tumor size (P = 0.036), and portal vein invasion (P = 0.005). Kaplan-Meir curve analysis demonstrated that HCC patients with higher AROS levels had shorter disease-free survival (DFS) in both the short-term (P < 0.001) and long-term (P = 0.005) compared to those with low AROS. Cox regression analysis demonstrated that AROS is a significant predictor for DFS along with large tumor size, tumor multiplicity, vascular invasion, and poor tumor differentiation, which are the k...Continue Reading
References
Oct 1, 1988·Cancer·S R SmalleyK Batts
May 1, 1984·Seminars in Liver Disease·M C Kew, H Popper
May 1, 1995·Cancer·F TrevisaniM Bernardi
Jan 1, 1995·World Journal of Surgery·H BismuthD Castaing
Jan 1, 1996·American Journal of Clinical Pathology·U C NzeakoK G Ishak
Oct 13, 1999·Seminars in Liver Disease·F X BoschJ Borràs
Apr 12, 2001·The British Journal of Surgery·N NagasueM Uchida
Aug 20, 2002·Genome Biology·Jo VandesompeleFrank Speleman
Mar 27, 2003·World Journal of Surgery·Miin-Fu ChenChao-Ming Hung
Feb 4, 2005·The Journal of Clinical Investigation·Ramón Bataller, David A Brenner
Nov 1, 2005·Journal of the American College of Surgeons·Christophe LaurentJean Saric
Nov 18, 2005·Biochemical and Biophysical Research Communications·Noriko MaedaTatsuo Tanaka
Aug 25, 2006·Nature Reviews. Cancer·Paraskevi A Farazi, Ronald A DePinho
Oct 30, 2007·Molecular Cell·Eun-Joo KimSoo-Jong Um
Nov 14, 2008·Digestive Surgery·Li XuYun-fei Yuan
Nov 20, 2008·BMB Reports·Eun-Joo Kim, Soo-Jong Um
Sep 26, 2009·PloS One·Stéphane BelinJean-Jacques Diaz
Oct 16, 2009·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Franco TrevisaniMauro Bernardi
May 26, 2010·Oncogene·C Deisenroth, Y Zhang
Jul 16, 2010·Nature Reviews. Gastroenterology & Hepatology·Ju Dong Yang, Lewis R Roberts
Sep 21, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jung-Hee KwonKwan Yong Choi
Dec 8, 2011·Annals of Surgical Oncology·Hsieh-Cheng ChenYu-Ling Chen
Jan 28, 2012·Cancer Research·Giulio DonatiMassimo Derenzini
Oct 2, 2012·PloS One·Kyu Yun JangKarl G Sylvester
Oct 12, 2012·Annals of the New York Academy of Sciences·Na-Young Song, Young-Joon Surh
Mar 7, 2013·Nucleic Acids Research·John R P KnightJo Milner
Jun 20, 2013·Surgery·Rachel E BeardRebecca A Miksad
Nov 22, 2013·Open Biology·John R P KnightJo Milner