Arousal-induced cortical activity triggers lactate release from astrocytes.

Nature Metabolism
Marc ZuendBruno Weber

Abstract

It has been suggested that, in states of arousal, release of noradrenaline and β-adrenergic signalling affect long-term memory formation by stimulating astrocytic lactate production from glycogen. However, the temporal relationship between cortical activity and cellular lactate fluctuations upon changes in arousal remains to be fully established. Also, the role of β-adrenergic signalling and brain glycogen metabolism on neural lactate dynamics in vivo is still unknown. Here, we show that an arousal-induced increase in cortical activity triggers lactate release into the extracellular space, and this correlates with a fast and prominent lactate dip in astrocytes. The immediate drop in astrocytic lactate concentration and the parallel increase in extracellular lactate levels underline an activity-dependent lactate release from astrocytes. Moreover, when β-adrenergic signalling is blocked or the brain is depleted of glycogen, the arousal-evoked cellular lactate surges are significantly reduced. We provide in vivo evidence that cortical activation upon arousal triggers lactate release from astrocytes, a rise in intracellular lactate levels mediated by β-adrenergic signalling and the mobilization of lactate from glycogen stores.

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Citations

Nov 17, 2020·Frontiers in Cellular Neuroscience·Susanne KöhlerUlrike Winkler
Dec 6, 2020·Glia·Ignacio Fernández-MoncadaLuis Felipe Barros
Nov 3, 2020·Frontiers in Cellular Neuroscience·Mithilesh Kumar Jha, Brett M Morrison
Mar 16, 2021·Frontiers in Cellular Neuroscience·Jérôme Wahis, Matthew G Holt
May 8, 2021·Current Opinion in Biomedical Engineering·Philipp MächlerAnna Devor
Mar 17, 2021·Biological Psychiatry·Amalia Floriou-ServouJohannes Bohacek
May 29, 2021·Frontiers in Cell and Developmental Biology·Alexandria N Hughes
Jun 9, 2021·Seminars in Cell & Developmental Biology·Mara Mather
Jul 23, 2021·Science Advances·Ryan V RautMarcus E Raichle
Jul 7, 2021·ELife·Chaim GlückBruno Weber
Aug 27, 2021·Metabolites·María Fernanda Veloz CastilloCorrado Calì
Aug 28, 2021·Brain Sciences·Barbara Vaccari CardosoAnja G Teschemacher

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Methods Mentioned

BETA
biosensor
Fluorescence
Protein Assay

Software Mentioned

ImageJ
R package pwr
corrplot
LabVIEW
multcomp
Camware
RCaMP
GCaMP6s
ScanImage
lsmeans

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