Array comparative genomic hybridization analysis revealed four genomic prognostic biomarkers for primary gastric cancers

Cancer Genetics and Cytogenetics
Nobumoto TomiokaSatoru Todo

Abstract

Unlike the case with some other solid tumors, whole genome array screening has not revealed prognostic genetic aberrations in primary gastric cancer. Comparative genomic hybridization (CGH) using bacterial artificial chromosome (BAC) arrays for 56 primary gastric cancers resulted in identification of four prognostic loci in this study: 6q21 (harboring FOXO3A; previously FKHRL1), 9q32 (UGCG), 17q21.1 approximately q21.2 (CASC3), and 17q21.32 (HOXB3 through HOXB9). If any one of these four loci was deleted, the prognosis of the patient was significantly worse (P = 0.0019). This was true even for advanced tumors (stage IIIA, IIB, or IV, n = 39) (P = 0.0113), whereas only 1 of the 17 patients with less advanced tumors (stage IA, IB, or II; n = 17) died of disease after surgery. Multivariate analysis according to the status of four BACs or pathological stage based on the Japanese Classification of Gastric Carcinoma (stages IA, IB, and II vs. stages IIIA, IIIB, and IV) demonstrated that the BAC clone status was also an independent prognostic factor (P = 0.006). These findings may help predict which patients with malignant potential need more intensive therapy, or may point to new therapeutic approaches especially for advanced tumors....Continue Reading

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Citations

Jan 28, 2014·Biochemical and Biophysical Research Communications·Fangyi LiLizhi Bai
Aug 20, 2014·Nature Reviews. Gastroenterology & Hepatology·Mairi H McLean, Emad M El-Omar
Jan 29, 2016·Journal of Crohn's & Colitis·Qiao YuMinhu Chen
Mar 4, 2014·Biochemical and Biophysical Research Communications·Liping FangLijuan Zou
Feb 15, 2014·International Journal of Radiation Biology·Katrin MäbertAnna Dubrovska
Mar 5, 2016·World Journal of Gastroenterology : WJG·Małgorzata SkieruchaRobert Sitarz
Aug 29, 2018·International Journal of Molecular Sciences·Michela CoanMilena Sabrina Nicoloso

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