Array technology and proteomics in autoimmune diseases

Pathology, Research and Practice
Veit KrennKarl Skriner

Abstract

Two new technologies (tissue microarrays (TMAs) and proteomics) have generated a great amount of data in life science. High-density TMAs allow for the simultaneous analysis of proteins and RNA by various methods (immunohistochemistry, in situ hybridization, FISH) on a large scale and under highly standardized conditions. Proteomics includes a variety of techniques that are partly high throughput. These techniques aim at the innovation of proteins, the description of the domain structure, the determination of protein sequences and epitope characterization, and ultimately the definition of protein function and protein reactivities in immunologic processes. Proteins that have been characterized accordingly require validation mostly at the morphologic level of defined tissue, linking proteomics to TMAs. In autoimmune diseases, array-based antigenic fingerprinting of autoantibodies will drive the development and the selection of antigen-specific diagnostic tools and therapies. The powerful combination of genomics and proteomics formed in tissue arrays has the potential to change the way the biology of autoimmunity is studied. Novel targets of drug discovery, based on antigen-specific therapies to induce anergy, or regulatory T-cells...Continue Reading

References

Apr 1, 1995·Seminars in Arthritis and Rheumatism·C A von Mühlen, E M Tan
Sep 1, 1997·Clinical Immunology and Immunopathology·D L JacobsonN M Graham
Jul 14, 1998·Nature Medicine·J KononenO P Kallioniemi
Jun 24, 2000·Nature·A Pandey, M Mann
Aug 2, 2000·Proceedings of the National Academy of Sciences of the United States of America·S P GygiR Aebersold
Jan 11, 2001·Advances in Anatomic Pathology·H MochG Sauter
Feb 22, 2001·Science·J C VenterX Zhu
Apr 3, 2001·Combinatorial Chemistry & High Throughput Screening·G WalterH Lehrach
Apr 18, 2001·International Archives of Allergy and Immunology·R CrameriG Walter
May 1, 2001·Annals of Medicine·O P Kallioniemi
Dec 6, 2001·The American Journal of Pathology·J TorhorstG Sauter
Apr 1, 1997·Chemical Reviews·George P. Smith, Valery A. Petrenko
Mar 5, 2002·Nature Medicine·William H RobinsonPaul J Utz
Jun 18, 2002·Trends in Molecular Medicine·Gerald WalterJörn Glökler
Jul 31, 2002·Journal of Clinical Pathology·G Sauter, M Mirlacher
Aug 14, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·K BüssowG Walter
Oct 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Viktor RoschkeThi-Sau Migone
Dec 17, 2002·Experimental Hematology·Ronald Simon, Guido Sauter
Jul 10, 2003·Autoimmunity Reviews·Glinda S Cooper, Berrit C Stroehla
Aug 2, 2003·Molecular Pathology : MP·J PackeisenH Buerger
Oct 2, 2003·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·B Jahn-SchmidM W Mueller
Nov 5, 2003·Proteomics·William H RobinsonPaul J Utz
Nov 26, 2003·Neurotoxicology·Richard M LoPachinDavid S Barber

❮ Previous
Next ❯

Citations

Jul 1, 2004·Arthritis Research & Therapy·Thomas HäuplGerd R Burmester
Sep 25, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Yifat Merbl, Marc W Kirschner
Sep 9, 2015·Zeitschrift für Rheumatologie·B StuhlmüllerT Häupl
Mar 13, 2015·Proteomics. Clinical Applications·Paul Cutler, Hans Voshol
Mar 23, 2012·Sensors·Noelia DasilvaManuel Fuentes
Jan 1, 2007·Proteomics. Clinical Applications·Elzbieta PastwaRichard Idem Somiari
Jan 1, 2006·Toxicology Mechanisms and Methods·Leigh Ann Burns-NaasStephen B Pruett
Jan 13, 2006·Current Opinion in Chemical Biology·William H Robinson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.