Arrays for the combinatorial exploration of cell adhesion

Journal of the American Chemical Society
Brendan P OrnerLaura L Kiessling

Abstract

A new method for the fabrication of arrays of self-assembled monolayers (SAMs) of alkane thiols (ATs) on gold to combinatorially assay surfaces for cell adhesion is reported. A fluorous SAM, which is both cytophobic and solvophobic, was used as the background between the array features. The resulting solvophobic background permits the application of an assembly after conjugation strategy for fabrication. SAMs containing mixtures of ATs and peptide-terminated ATs were generated. Multiple cell types demonstrated differential and specific binding to these surfaces. Additionally, pluripotent human embryonic stem cells proliferated on surfaces generated by this method.

References

Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·B J SpargoA S Rudolph
Dec 1, 1993·Journal of Biomedical Materials Research·S MargelD Y Sogah
Apr 29, 1994·Science·R SinghviD E Ingber
Jul 1, 1993·Journal of Biomedical Materials Research·J P RanieriP Aebischer
Nov 6, 1998·Science·J A ThomsonJ M Jones
May 17, 2001·Proceedings of the National Academy of Sciences of the United States of America·M N YousafM Mrksich
Jan 5, 2002·Biomaterials·Helga SorribasLouis Tiefenauer

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Citations

Jan 14, 2010·Journal of the American Chemical Society·Ratmir DerdaLaura L Kiessling
Nov 30, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·Woon-Seok Yeo, Milan Mrksich
Sep 21, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Ratmir DerdaLaura L Kiessling
Feb 13, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Matthew R Lockett, Lloyd M Smith
Oct 28, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Justin T Koepsel, William L Murphy
Feb 14, 2006·Nature Chemical Biology·Srinivasa-Gopalan SampathkumarKevin J Yarema
Aug 3, 2005·Nature Reviews. Cancer·Mark M Fuster, Jeffrey D Esko
Nov 14, 2012·Integrative Biology : Quantitative Biosciences From Nano to Macro·Justin T KoepselWilliam L Murphy
Sep 16, 2008·Proceedings of the National Academy of Sciences of the United States of America·Bahram ValamehrHong Wu
Feb 19, 2010·Tissue Engineering. Part B, Reviews·Lilia Araida Hidalgo-Bastida, Sarah H Cartmell
Aug 24, 2010·Tissue Engineering. Part C, Methods·Lynn Y W YapWilliam R Birch
Apr 19, 2008·Journal of Biomaterials Science. Polymer Edition·L MoroniC A van Blitterswijk
May 17, 2011·PloS One·Ratmir DerdaGeorge M Whitesides
Feb 9, 2012·International Journal of Molecular Sciences·Paweł SzymańskiElżbieta Mikiciuk-Olasik
Jul 2, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lingyin LiLaura L Kiessling
Jan 12, 2008·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Jun NakanishiMizuo Maeda
Jan 26, 2016·Acta Biomaterialia·Edith LinRatmir Derda
Mar 3, 2009·Acta Biomaterialia·Milan Mrksich
Sep 2, 2006·Journal of Biomedical Materials Research. Part a·Ying MeiLori Henderson
Jan 16, 2008·Journal of Cellular and Molecular Medicine·C M MetalloS P Palecek
Oct 27, 2015·Acta Biomaterialia·Robert CoyleYing Mei
Aug 4, 2006·Biomaterials·Jeffrey C MohrSean P Palecek
Jul 29, 2006·Chemistry & Biology·Daniel J KenanMark W Grinstaff
Feb 23, 2011·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ratmir DerdaMohammad R Jafari
Jul 28, 2016·Nature Communications·Regino Mercado-LuboBeth A McCormick
Dec 13, 2006·Chembiochem : a European Journal of Chemical Biology·Robert M OwenLaura L Kiessling
May 28, 2008·Angewandte Chemie·George Pasparakis, Cameron Alexander
Dec 3, 2015·Nanotechnology·Stefano TebiStefan Müllegger
Jun 1, 2013·Reports on Progress in Physics·Rajagopalan ThiruvengadathanShubhra Gangopadhyay
Dec 22, 2017·PloS One·Jose Torres-JimenezOscar Carrizalez-Turrubiates
Nov 16, 2010·Nature Methods·Joseph R KlimLaura L Kiessling
Jul 19, 2012·Chembiochem : a European Journal of Chemical Biology·Justin T Koepsel, William L Murphy
Jul 21, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Douglas Zhang, Kristopher A Kilian
Oct 29, 2017·Biomaterials·Jungmok SeoAli Khademhosseini

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