Arrest of flagellum morphogenesis with fibrous sheath immaturity of human spermatozoa

Andrologia
D Escalier

Abstract

Morphogenesis of the mammalian sperm flagellum is characterized by the assembly of axonemal and peri-axonemal structures. The incorporation of mitochondria into the flagellum results from complex cellular events, including flagellum compartmentalization and membrane and organelle reorganization. These events are striking in the annulus, which progressively relocates from the neck to the principal piece of the flagellum. This study presents a human sperm phenotype with failure of the annulus relocation, absence of mitochondrial sheath and a fibrous sheath at intermediate step of assembly. The sperm nucleus was fully condensed but with deep invaginations engulfing the acrosome. The distal pole of some mitochondria exhibited an unusual dense substance. This rare human sperm phenotype was found in a consanguineous patient, suggesting a genetic origin. These anomalies raise the question of the mechanisms that lead to impairment of both the annulus relocation and the deposit of proteins on the fibrous sheath during spermiogenesis.

References

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Citations

Mar 31, 2010·Journal of Assisted Reproduction and Genetics·Hsin-Chih Albert ChaoPao-Lin Kuo
Apr 6, 2012·Zygote : the Biology of Gametes and Early Embryos·Marco Antonio Arenas NúñezMaría Elena Trujillo Ortega
Feb 18, 2009·Human Reproduction·P LhuillierA Touré
May 31, 2012·Médecine sciences : M/S·Denise Escalier, Aminata Touré
Mar 17, 2016·Systems Biology in Reproductive Medicine·Elena MorettiGiulia Collodel
Sep 8, 2009·International Journal of Andrology·S S TangS Ma
Apr 23, 2010·International Journal of Urology : Official Journal of the Japanese Urological Association·Vincenzo ViscoFernando Mazzilli
Aug 26, 2006·Gynécologie, obstétrique & fertilité·D Escalier
Mar 15, 2019·Basic and Clinical Andrology·Jean-Fabrice Nsota MbangoAminata Touré
Jan 18, 2020·Human Genetics·Aminata TouréCharles Coutton

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