PMID: 9450683Feb 5, 1998Paper

Arrestin and phosducin are expressed in a small number of brain cells

Brain Research. Molecular Brain Research
K Sunayashiki-KusuzakiT Shinohara

Abstract

Retinal photoreceptor rods and pinealocytes contain well-characterized proteins such as arrestin and phosducin whose expression is highly restricted to these cell types. Transgenic mice having a LacZ gene under the control of an arrestin promoter expressed beta-galactosidase (beta-Gal) in the photoreceptor rods and pinealocytes. In addition, it was expressed in very small numbers of discrete cells in the habenular commissura, amygdala, ventral tegmental area and superior colliculus of the brain. Immunocytochemical studies with antibody probes revealed that high level of arrestin and phosducin were also found in the same cell types. Furthermore melatonin was found in those cells of the habenula commissura. The results indicate that novel cell types are present in the brain tissues. Since high levels of arrestin and phosducin expression are generally restricted to photoreceptor rod cells and pinealocytes, these data suggest that certain brain cells may have functions similar to pinealocytes.

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Citations

May 17, 2002·Neuropharmacology·J GarzónP Sánchez-Blázquez
Nov 6, 2001·Journal of Neuroimmunology·D S Gregerson, J Xiao
Jun 26, 2004·Annual Review of Neuroscience·Raul R GainetdinovMarc G Caron
Jul 3, 2007·PLoS Pathogens·Matthew E Rogers, Paul A Bates
Nov 12, 2010·Cellular and Molecular Life Sciences : CMLS·Nadine Beetz, Lutz Hein
Dec 16, 2005·Glia·Scott W McPhersonDale S Gregerson
Feb 24, 2001·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·R Schulz
Aug 27, 2002·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Patrick J Dolph
Jan 6, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neal D HeussDale S Gregerson
Jan 6, 2001·Cell Transplantation·J Sanchez-RamosE Y Snyder

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