Arresting Dentine Caries with Silver Diamine Fluoride: What's Behind It?

Journal of Dental Research
M L MeiC H Chu

Abstract

Unlike other fluoride-based caries preventive agents, silver diamine fluoride (SDF) can simultaneously prevent and arrest coronal and root dentine caries. The profound clinical success of SDF has drawn many clinicians and researchers to study the mechanism of SDF in arresting dentine caries. This critical review discusses how silver and fluoride contribute to caries arrest, in terms of their effects on bacteria as well as on the mineral and organic content of dentine. Silver interacts with bacterial cell membrane and bacterial enzymes, which can inhibit bacterial growth. Silver can also dope into hydroxyapatite and have an antibacterial effect on silver-doped hydroxyapatite. Furthermore, silver is also a strong inhibitor of cathepsins and inhibits dentine collagen degradation. Early studies proposed that silver hardened caries lesions by forming silver phosphate. However, recent studies found that little silver phosphate remained on the arrested dentine lesion. The principal silver precipitate was silver chloride, which could not contribute to the significant hardening of the arrested lesions. On the other hand, fluoride enhances mineral formation by forming fluorohydroxyapatite with reduced solubility. A significant increase i...Continue Reading

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Citations

Jan 15, 2019·International Journal of Paediatric Dentistry·Marcela Baraúna MagnoAndréa Fonseca-Gonçalves
Jun 5, 2020·BMC Oral Health·Kausar Sadia FakhruddinLakshman Perera Samaranayake
May 6, 2020·International Journal of Nanomedicine·Irene Shuping ZhaoChun Hung Chu
May 23, 2020·International Journal of Nanomedicine·Iris Xiaoxue YinChun Hung Chu
Jul 7, 2020·Dental Materials Journal·Hamid NurrohmanGrayson W Marshall
Jan 3, 2021·European Archives of Paediatric Dentistry : Official Journal of the European Academy of Paediatric Dentistry·H M AbdellatifM A ElKateb
Jan 4, 2021·Journal of Dentistry·Nousha Panahpour EslamiAlireza Sadr
Jan 28, 2021·European Journal of Oral Sciences·Maria Jacinta Rosario H Romero, Frank Lippert
Mar 19, 2021·Dental Materials Journal·Motoi TakahashiJunji Tagami
Apr 23, 2021·Journal of Applied Oral Science : Revista FOB·Seunggun KimJunji Tagami
Nov 30, 2018·Dental Materials : Official Publication of the Academy of Dental Materials·Ollie Yiru YuChun-Hung Chu
Jun 28, 2021·Journal of Dentistry·John Yun NiuChun Hung Chu
Aug 16, 2021·Journal of Dentistry·Chloe Meng JiangChun Hung Chu
Aug 27, 2021·ACS Biomaterials Science & Engineering·Wen QinLi-Na Niu

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Methods Mentioned

BETA
X-ray
transmission electron microscopy
electron diffraction
scanning electron microscopy

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