Arresting supporters: targeting neutrophils in metastasis

Cell Research
Swarnali Acharyya, Joan Massague

Abstract

It is becoming increasingly clear that leukocytes dynamically regulate cancer progression and metastasis, and among leukocytes, granulocytic cells abundantly accumulate in metastatic organs; however, their function in metastasis remains controversial. In a recent report in Nature, Wculek and Malanchi clarify the role of mature neutrophils as mediators of metastatic initiation and provide a targeted approach to prevent the pro-metastatic activity of neutrophils in breast cancer models.

References

Jan 1, 1995·The Journal of Experimental Medicine·L A PekarekH Schreiber
Mar 13, 2009·Nature Reviews. Cancer·Johanna A Joyce, Jeffrey W Pollard
May 7, 2009·Allergy·N P DuroudierI Sayers
Nov 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marcin KowanetzNapoleone Ferrara
Sep 13, 2011·Cancer Cell·Zvi GranotRobert Benezra
Mar 24, 2012·Cancer Cell·Douglas Hanahan, Lisa M Coussens
Jul 10, 2012·Cell·Swarnali AcharyyaJoan Massagué
Oct 24, 2014·Annual Review of Medicine·Thomas CondamineDmitry I Gabrilovich
Dec 10, 2015·Nature·Stefanie K Wculek, Ilaria Malanchi
Jan 23, 2016·Nature·Joan Massagué, Anna C Obenauf

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Citations

Apr 7, 2017·Macromolecular Bioscience·Matthias Bartneck
Nov 25, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jei-Ming PengSen-Yung Hsieh
Mar 28, 2018·Cancer Biology & Therapy·Liting JinXiaojiang Cui
Aug 27, 2019·Frontiers in Immunology·Kangsan KimSrinivas Malladi

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