Arrhenius activation energy of damage to catalase during spray-drying

International Journal of Pharmaceutics
Joachim Schaefer, Geoffrey Lee

Abstract

The inactivation of catalase during spray-drying over a range of outlet gas temperatures could be closely represented by the Arrhenius equation. From this an activation energy for damage to the catalase could be calculated. The close fit to Arrhenius suggests that the thermally-induced part of inactivation of the catalase during the complex drying and particle-formation processes takes place at constant temperature. These processes are rapid compared with the residence time of the powder in the collecting vessel of the cyclone where dried catalase is exposed to a constant temperature equal to approximately the drying gas outlet temperature. A lower activation energy after spray drying with the ultrasonic nozzle was found than with the 2-fluid nozzle under otherwise identical spray drying conditions. It is feasible that the ultrasonic nozzle when mounted in the lid of the spray dryer heats up toward the drying gas inlet temperature much more that the air-cooled 2-fluid nozzle. Calculation of the Arrhenius activation energy also showed how the stabilizing efficacy of trehalose and mannitol on the catalase varies in strength across the range of drying gas inlet and outlet temperatures examined.

References

Jan 1, 1997·Journal of Pharmaceutical Sciences·B C Hancock, G Zografi
Aug 1, 1997·Pharmaceutical Development and Technology·Y F MaaC C Hsu
Nov 14, 1998·Biochimica Et Biophysica Acta·W Q SunH S Chan
Feb 9, 1999·Journal of Pharmaceutical Sciences·M Adler, G Lee
Jul 27, 2001·Current Pharmaceutical Biotechnology·Y F Maa, S J Prestrelski
Mar 12, 2005·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Michael MauryGeoffrey Lee
Mar 22, 2005·International Journal of Pharmaceutics·Kenneth C Waterman, Roger C Adami

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Citations

Sep 19, 2015·International Journal of Pharmaceutics·Juan DuYancai Wang
Jul 3, 2015·Pharmaceutical Development and Technology·Joachim Schaefer, Geoffrey Lee
Feb 7, 2021·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Christoph MarschallWolfgang Friess
Mar 14, 2018·Progress in Biophysics and Molecular Biology·Hessam Sepasi Tehrani, Ali Akbar Moosavi-Movahedi

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