Abstract
Liver transplantation (LT) is a potentially curative treatment for hereditary transthyretin amyloidosis, of which familial amyloid polyneuropathy (FAP) is the most common form in Sweden. This study investigated the long-term development in heart rate variability (HRV) after LT in Swedish FAP patients. HRV was analyzed before LT, and during a first (<40 months) and a second (>40 months) follow-up recording after transplantation, respectively. Power spectrum analysis was performed on 2-min sequences in the supine position and after passive tilt, after careful identification of patients with arrhythmia. Data were obtained from 33 patients, but 18 patients had developed cardiac arrhythmia or were pacemaker-treated (4 before LT and 14 after LT) and three patients had not performed the first follow-up recording. In the remaining 12 patients, HRV decreased between the pretransplant evaluation and the first follow-up, thereafter no significant changes were found. In conclusion, our study showed that the progressive development of cardiac arrhythmias after LT is a major pitfall when assessing cardiac autonomic function in FAP patients, especially in patients older than 40 years. In the minority of patients with sinus rhythm in all recor...Continue Reading
References
Jun 1, 1991·Human Pathology·K TakahashiS Araki
Dec 1, 1987·Journal of the Autonomic Nervous System·F WeiseU Runge
Jun 1, 1995·The British Journal of Surgery·P ParrillaM Munar-Ques
Jan 21, 1995·Lancet·Y AndoM Ando
May 1, 1993·Lancet·G HolmgrenP N Hawkins
Aug 27, 1996·Journal of the Autonomic Nervous System·M AbeT Kano
Mar 15, 1997·Transplantation·O B SuhrB O Olofsson
Nov 14, 1997·Journal of Internal Medicine·O B SuhrB O Olofsson
Apr 13, 1999·European Journal of Nuclear Medicine·N DelahayeD Le Guludec
Nov 4, 2000·Scandinavian Journal of Gastroenterology·K LångO B Suhr
Mar 22, 2002·Transplantation·Bert-Ove OlofssonOle B Suhr
Sep 11, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Ole B SuhrAnders Rydh
Dec 3, 2003·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Lawreen Heller ConnorsCatherine E Costello
Jul 17, 2004·Transplantation·Rolf HörnstenOle B Suhr
Sep 22, 2005·Journal of Cardiovascular Electrophysiology·Phyllis K SteinJohn Gottdiener
Jan 3, 2006·Journal of Electrocardiology·Rolf HörnstenSteen M Jensen
Sep 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S YamamotoB-G Ericzon
May 20, 2008·Journal of Neurology·Yoshio ShimojimaShu-ichi Ikeda
Aug 21, 2008·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Urban WiklundSteen M Jensen
Oct 18, 2008·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Rolf HörnstenUrban Wiklund
Dec 17, 2008·Internal Medicine·Sadahisa OkamotoMakoto Uchino
May 19, 2010·Autonomic Neuroscience : Basic & Clinical·Urban WiklundOle B Suhr
Oct 12, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Konen ObayashiOle B Suhr
Nov 9, 2010·International Journal of Cardiology·Ying ZhaoMichael Y Henein
Feb 1, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Sadahisa OkamotoOle B Suhr
Aug 16, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·H E WilczekUNKNOWN FAPWTR