Arrhythmia discrimination using hemoglobin spectroscopy in humans

Heart Rhythm : the Official Journal of the Heart Rhythm Society
S J ComptonS K Bhunia

Abstract

Inappropriate therapies are frequently delivered by implantable cardioverter-defibrillators (ICDs). We have investigated muscle perfusion as a means of augmenting arrhythmia discrimination by using implanted near-infrared spectroscopy. To evaluate hemodynamic stability by monitoring muscle perfusion from within the ICD pocket, in fresh tissue and inside the scar capsule on preexisting ICD generators, during induced cardiac arrhythmias, in humans. The sensor was implanted on or under the pectoral muscle, during ICD defibrillation threshold testing. A microvascular oxygenation trend indicator (O2 Index) was computed during 74 induced ventricular fibrillation and 34 normal sinus rhythm episodes in 34 patients and also during 28 atrial and 90 ventricular overdrive pacing episodes as simulations of supraventricular and ventricular tachycardias, respectively. On average, the change in oxygenation, based on the O2 Index, was statistically significant (P <.003) from baseline within 3 seconds following cardiac arrest. An optimized O2 Index, used for detecting the hemodynamic trend, exhibited a decreasing trend during ventricular fibrillation (P <.0001) and was different from that during normal sinus rhythm (P <.0001). The sensitivity fo...Continue Reading

References

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Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Navinder S SawhneyMitchell N Faddis
Apr 5, 2008·Journal of the American College of Cardiology·James P DaubertUNKNOWN MADIT II Investigators
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Aug 6, 2009·Circulation. Arrhythmia and Electrophysiology·Gregory WalcottRaymond Ideker

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Citations

Jun 5, 2012·Heart Rhythm : the Official Journal of the Heart Rhythm Society·William W Brabham, Michael R Gold
Jun 22, 2019·JACC. Clinical Electrophysiology·Daniel KeeneZachary I Whinnett

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