PMID: 6982689Oct 1, 1982Paper

Arrhythmia prophylaxis using propranolol after coronary artery surgery

The Annals of Thoracic Surgery
J B WilliamsM E Josephson

Abstract

Sixty patients undergoing coronary artery bypass grafting operations with cold potassium cardioplegia as the method of myocardial preservation either received low-dose oral propranolol (10 mg every 6 hours; 28 patients) or served as controls (32 patients). The study period began after extubation and ended at the time of hospital discharge. On the fourth postoperative day, 24-hour Holter monitoring was performed to assess additional subtle differences in arrhythmias. The overall incidence of symptomatic postoperative arrhythmias was 31% in the control group: 6 patients (19%) had atrial fibrillation or flutter and 4 patients (12%), ventricular arrhythmias. By contrast, 1 patient (4%) in the propranolol group had atrial fibrillation, and no patient had ventricular arrhythmias. The difference in overall arrhythmia rates between the two groups is significant (p less than 0.025). Twenty-four-hour Holter monitoring demonstrated no additional differences in the frequency of simple or complex atrial or ventricular ectopy between the two groups. We conclude that the incidence of postoperative arrhythmias following coronary artery bypass operation is diminished by the oral administration of prophylactic low-dose propranolol. When compared...Continue Reading

References

Feb 1, 1978·The Annals of Thoracic Surgery·M M KirshH Sloan
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Sep 1, 1966·The American Journal of Cardiology·A Harris
Apr 1, 1967·Annals of Internal Medicine·R GianellyD C Harrison

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Citations

May 1, 1992·Chest·G H AlmassiG N Olinger
Jul 1, 1985·The Annals of Thoracic Surgery·Y F Chen, Y T Lin
Jul 1, 1985·International Journal of Cardiology·P MaterneH Kulbertus
Mar 14, 2018·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Sep 19, 2014·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Feb 1, 1985·Australian and New Zealand Journal of Medicine·T P GavaghanJ J Morgan
Nov 6, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·K MatsuuraK Ishida
Mar 10, 2001·Nature·L M Prockter
Sep 24, 2019·The Cochrane Database of Systematic Reviews·Hermann BlessbergerClemens Steinwender
Feb 27, 2013·The Cochrane Database of Systematic Reviews·Kyle A ArsenaultRichard P Whitlock

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