Arrhythmias in adult patients with congenital heart disease and pulmonary arterial hypertension

Heart
Maria DrakopoulouKonstantinos Dimopoulos

Abstract

Approximately 5%-10% of adults with congenital heart disease (CHD) develop pulmonary arterial hypertension (PAH), which affects life expectancy and quality of life. Arrhythmias are common among these patients, but their incidence and impact on outcome remains uncertain. All adult patients with PAH associated with CHD (PAH-CHD) seen in a tertiary centre between 2007 and 2015 were followed for new-onset atrial or ventricular arrhythmia. Clinical variables associated with arrhythmia and their relation to mortality were assessed using Cox analysis. A total of 310 patients (mean age 34.9±12.3 years, 36.8% male) were enrolled. The majority had Eisenmenger syndrome (58.4%), 15.2% had a prior defect repair and a third had Down syndrome. At baseline, 14.2% had a prior history of arrhythmia, mostly supraventricular arrhythmia (86.4%). During a median follow-up of 6.1 years, 64 patients developed at least one new arrhythmic episode (incidence 3.47% per year), mostly supraventricular tachycardia or atrial fibrillation (78.1% of patients). Arrhythmia was associated with symptoms in 75.0% of cases. The type of PAH-CHD, markers of disease severity and prior arrhythmia were associated with arrhythmia during follow-up. Arrhythmia was a strong p...Continue Reading

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Citations

Sep 6, 2019·International Heart Journal·Zhi WangYi-Qing Yang
Jun 21, 2020·Medicina·Dovilė JančauskaitėLina Gumbienė
Mar 17, 2020·Journal of the American Heart Association·Anca ChiriacChristopher J McLeod
Jul 26, 2019·Current Treatment Options in Cardiovascular Medicine·Karine GuerrierGlenn T Wetzel
Aug 14, 2019·Heart Failure Reviews·Michail PapamichalisFilippos Triposkiadis
May 24, 2019·Expert Review of Cardiovascular Therapy·Carla FavocciaKonstantinos Dimopoulos
Dec 21, 2019·European Heart Journal Supplements : Journal of the European Society of Cardiology·Laurent Savale, Alessandra Manes
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Jul 22, 2020·Heart·Alexandra ArvanitakiAstrid Elisabeth Lammers
Dec 20, 2020·Journal of Cardiovascular Development and Disease·Mary N Sheppard
Dec 23, 2020·Journal of Clinical Medicine·Susanne J MaurerOktay Tutarel
Mar 9, 2021·Journal of Cardiovascular Electrophysiology·Jing X QuahAnand Ganesan
Apr 16, 2021·Expert Review of Cardiovascular Therapy·Ana Barradas-PiresKonstantinos Dimopoulos
Jun 25, 2021·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Elizabeth B Malinzak

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