Arrhythmias in the Heart Transplant Patient

Arrhythmia & Electrophysiology Review
David HamonNoel G Boyle

Abstract

Orthotopic heart transplantation (OHT) is currently the most effective long-term therapy for patients with end-stage cardiac disease, even as left ventricular devices show markedly improved outcomes. As surgical techniques and immunosuppressive regimens have been refined, short-term mortality caused by sepsis has decreased, while morbidity caused by repeated rejection episodes and vasculopathy has increased, and is often manifested by arrhythmias. These chronic transplant complications require early and aggressive multidisciplinary treatment. Understanding the relationship between arrhythmias and these complications in the acute and chronic stages following OHT is critical in improving patient prognosis, as arrhythmias may be the earliest or sole presentation. Finally, decentralised/ denervated hearts represent a unique opportunity to investigate the underlying mechanisms of arrhythmias.

Citations

Dec 28, 2019·Pediatric Transplantation·Nadim H NasserNadir N Nasir
Feb 29, 2020·Current Opinion in Cardiology·Michael A EskanderKurt S Hoffmayer
Sep 21, 2018·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Geoffrey RubinElaine Y Wan
Sep 18, 2020·Clinical Transplantation·Daniele MasaroneGiuseppe Pacileo
Sep 18, 2018·Progress in Transplantation : Official Publication, North American Transplant Coordinators Organization ... [et Al.]·Razan AlsheikhMajed S Al Yami
Jul 5, 2018·Clinical and Translational Science·Babar BashirWalter K Kraft
Jan 20, 2017·Pacing and Clinical Electrophysiology : PACE·Petra WellmannGerd Juchem
Mar 10, 2021·Circulation. Arrhythmia and Electrophysiology·Jose A JoglarRakesh Gopinathannair
Aug 21, 2020·JACC. Clinical Electrophysiology·Ersilia M DeFilippisHirad Yarmohammadi
Jun 2, 2021·Circulation·Jacinthe BouletMark Liszkowski

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