PMID: 11332576May 3, 2001Paper

Arrhythmogenesis in heart failure

Journal of Cardiovascular Electrophysiology
M J JanseL R Dekker

Abstract

In a rabbit model of heart failure produced by combined pressure and volume overload, nonsustained ventricular tachycardias developed in 15 of 23 failing rabbits. Sinus rate was increased in rabbits dying suddenly, but was decreased in survivors. This also was true in isolated preparations. Microelectrode recordings from ventricular trabeculae both from patients with end-stage failure and from failing rabbits showed that in half of the preparations, delayed afterdepolarizations and triggered activity occurred, but only in the presence of norepinephrine and a lowered extracellular K+ concentration of 3 mM. This was due to spontaneous release of Ca2+ from the sarcoplasmic reticulum.

Citations

Oct 13, 2006·Pflügers Archiv : European journal of physiology·David Z LanVladimir G Fast
Sep 6, 2005·Current Heart Failure Reports·Matthew W EbingerClaudio D Schuger
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