Arrival of afferents and the differentiation of target neurons: studies of developing cholinergic projections to the dentate gyrus

Neuroscience
R MakuchR T Robertson

Abstract

This study examined the relationship between the development of cholinergic axons originating from the septum and a group of their target cells, the granule cells of the dentate gyrus of the rat. Acetylcholinesterase histochemistry was used to identify septal cholinergic afferents to the dentate gyrus; parallel studies used anterograde movement of a carbocyanine dye to label the septal projections. Septal cholinergic axons are present in the molecular layer of the internal blade of the dentate gyrus shortly after birth, but these axons do not reach the external blade until several days later. Results demonstrate that acetylcholinesterase positive septal axons grow into the external blade of the dentate gyrus only after the recently generated granule cells have coalesced to form a clearly defined layer. Results from studies using in situ hybridization techniques demonstrate that dentate gyrus granule cells express messenger RNAs for brain derived neurotrophic factor and for neurotrophic factor 3 shortly after formation of the granule cell layer. Ingrowth of septal cholinergic axons follows two days after the formation of the external blade of the dentate gyrus and the expression of neurotrophin messenger RNAs by the dentate gran...Continue Reading

References

Dec 3, 1979·Life Sciences·J Lehmann, H C Fibiger
Dec 15, 1978·The Journal of Comparative Neurology·D G Amaral
Dec 1, 1991·Brain Research Bulletin·E GouldL L Butcher
Jan 1, 1990·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·R T RobertsonJ Yu
Nov 1, 1986·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H TagoT Maeda
Apr 1, 1989·Trends in Pharmacological Sciences·C F Dreyfus
May 1, 1989·Brain Research. Developmental Brain Research·D R BradyJ E Vaughn
Aug 1, 1988·Journal of Neuroscience Research·S R WhittemoreV R Holets
Mar 1, 1988·The Journal of Comparative Neurology·K Semba, H C Fibiger
Jun 1, 1965·The Journal of Comparative Neurology·J Altman, G D Das
Apr 17, 1995·The Journal of Comparative Neurology·C A Calarco, R T Robertson
Jan 1, 1994·Progress in Brain Research·L Landmesser
Feb 1, 1994·Molecular and Cellular Neurosciences·J C LauterbornC M Gall
Jan 1, 1993·Experimental Neurology·W J FriedmanI B Black
Dec 22, 1999·The Journal of Comparative Neurology·A J VigersK R Jones

❮ Previous
Next ❯

Citations

May 11, 2005·Brain Research. Developmental Brain Research·Kathleen M GuthrieRichard T Robertson
Dec 18, 2001·Brain Research. Developmental Brain Research·J BarattaR T Robertson
Jan 29, 2011·Behavioural Brain Research·Elodie Bruel-JungermanFiona Francis
Nov 21, 2009·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Randal G RossCatherine E Adams

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.