Arsenic aggravates oxidative stress causing hepatic alterations and inflammation in diabetic rats

Life Sciences
Ana Cláudia Ferreira SouzaMariana Machado-Neves

Abstract

Studies have shown that exposure to either environmental toxicants or hyperglycemia causes hepatic injuries. However, it is unclear the extent to which their combined exposure may influence liver functions. Therefore, we aimed to evaluate morphological and functional hepatic parameters in diabetic rats exposed to arsenic. Diabetes was induced in male rats by intraperitoneal streptozotocin injection. While healthy and diabetic animals received saline solution (negative control and diabetes control, respectively), other animals received 10 mg/L sodium arsenate (arsenic control and diabetes + arsenic groups, respectively) for 40 days in drinking water. Liver tissue was subjected to antioxidant enzymes analysis, cytokine assay, arsenic determination, and histopathological evaluation. Functional markers of hepatic damage were analyzed using serum samples. Arsenate exposure reduced the antioxidant enzymes activity in healthy rats, and it worsened the reduction of GST in diabetic animals. Consequently, arsenate-exposed animals showed increased malondialdehyde and carbonyl protein levels, being this increase worsened in diabetes + arsenic animals. Arsenate-exposed groups also showed hepatic inflammatory process with high number of mast...Continue Reading

Citations

Mar 9, 2019·Environmental Science and Pollution Research International·Marcela Nascimento SertorioMariana Machado-Neves
Sep 30, 2020·Environmental Science and Pollution Research International·Daifullah Al AboudRami B Kassab
Jan 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Renner Philipe Rodrigues CarvalhoMariana Machado-Neves
Mar 24, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Daniel Silva Sena BastosEduardo de Almeida Marques-da-Silva
Jul 28, 2020·Life Sciences·Ana Cláudia Ferreira SouzaMariana Machado-Neves
May 21, 2021·Environmental Science and Pollution Research International·Shaofeng WuLianmei Hu
Aug 25, 2021·Environmental Pollution·Md Shiblur RahamanSahoko Ichihara

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