PMID: 9448748Feb 4, 1998Paper

Arsenic and antimony: comparative approach on mechanistic toxicology

Chemico-biological Interactions
T Gebel

Abstract

A chemico-toxicological similarity between arsenic and antimony exists and their toxicology is often seen. Indeed, both elements possess several common properties, e.g. they are clastogenic but not mutagenic in the trivalent state and they have a carcinogenic potential: trivalent arsenicals are known to be human carcinogens and antimony(III) oxide (by inhalation) has been shown to cause lung cancer in female rats. For years, arsenic has been known to be environmentally toxic. Elevated human exposure to this element, mostly caused by the intake of contaminated tap water, is associated with increased incidences of cancer at various sites. It is still not clear how arsenic compounds exert their genotoxic effect. It may be connected with an inhibition of DNA repair or the induction of oxidative stress. Little work has been done on the toxicology of antimony as it is less widely present in the environment. There is evidence that in mammals antimony, unlike arsenic, is not detoxified via methylation but it still remains unclear what mechanism is responsible for antimony's genotoxicity. In general, there is little information known about this element to accurately determine its impact on human health. Thus, the aim of this paper is to...Continue Reading

References

Sep 15, 1979·Toxicology and Applied Pharmacology·G K TamE Sandi
Oct 1, 1975·CRC Critical Reviews in Toxicology·C D Klaassen
Aug 1, 1977·Environmental Health Perspectives·E A Crecelius
Dec 16, 1992·Mutation Research·A N JhaA T Natarajan
Jan 1, 1992·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·N GurnaniG Talukder
Mar 1, 1992·American Journal of Epidemiology·M N BatesC Hopenhayn-Rich
Aug 1, 1991·Toxicology and Applied Pharmacology·L A BurnsA E Munson
Dec 1, 1991·Mutation Research·K KurodaS Horiguchi
Jan 1, 1991·Human Heredity·I Nordenson, L Beckman
Mar 1, 1990·Critical Care Medicine·L F LauwersL Baute
Jul 1, 1989·Biological Trace Element Research·J H Li, T G Rossman
Jan 1, 1988·Transactions of the Royal Society of Tropical Medicine and Hygiene·J D ChulayD H Smith
Feb 20, 1988·Lancet·C J ChenM M Wu
Jan 1, 1986·Journal of Toxicology and Environmental Health·D H GrothL Wong
Jun 1, 1985·Archives of Toxicology·M Vahter, E Marafante
Aug 1, 1985·Archives of Toxicology·A B FischerR R Lauwerys
May 1, 1974·American Industrial Hygiene Association Journal·S A FelicettiR O McClellan
Aug 2, 1980·Lancet·P H ReesW T Hockmeyer
Jan 1, 1980·Environmental Mutagenesis·T G RossmanW Troll
Aug 1, 1984·Scandinavian Journal of Work, Environment & Health·P LefflerG F Nordberg
Oct 15, 1983·Chemico-biological Interactions·M Vahter, E Marafante
Aug 1, 1983·Chemico-biological Interactions·S A LermanR J Gerson
Jan 1, 1980·Journal of Toxicology and Environmental Health·L R GurleyR A Tobey
Jan 1, 1980·Mutation Research·A Léonard, R R Lauwerys
Jan 1, 1982·Archives of Toxicology·G B GerberB Eykens
Sep 1, 1982·Scandinavian Journal of Work, Environment & Health·L GerhardssonP O Wester
May 1, 1980·Toxicology and Applied Pharmacology·C PomroyG K Tam
Jan 1, 1995·Environmental and Molecular Mutagenesis·P Ramos-Morales, R Rodríguez-Arnaiz
Aug 1, 1995·Toxicology and Applied Pharmacology·M VahterR Nilsson
Jan 1, 1995·International Archives of Occupational and Environmental Health·M KentnerG Lehnert
May 1, 1993·Biological Trace Element Research·N GurnaniG Talukder

❮ Previous
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Citations

Jul 25, 2009·Archives of Environmental Contamination and Toxicology·Marcia BaezaThomas C Vaughan
Nov 4, 2010·Environmental Geochemistry and Health·Jeongyi AnMin Jang
Dec 4, 2003·Mutation Research·Marlies De BoeckDominique Lison
Jan 20, 2004·Toxicology and Applied Pharmacology·Paul AndrewesKathleen Wallace
Oct 24, 2002·Toxicology·Sentaro TakahashiRyuichi Okayasu
Mar 30, 2002·Critical Reviews in Oncology/hematology·Ann M Bode, Zigang Dong
Jun 7, 2002·Critical Reviews in Oncology/hematology·Edward R T Tiekink
Nov 29, 2012·Journal of Exposure Science & Environmental Epidemiology·Konstantinos C MakrisRuss Hauser
Jul 7, 2007·Food Additives and Contaminants·M HaldimannV Dudler
Dec 1, 2010·Food Additives & Contaminants. Part B, Surveillance·B L BatistaF Barbosa
Jan 5, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·M HaldimannV Dudler
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Ronald Bentley, Thomas G Chasteen
Aug 27, 2002·Environmental Health Perspectives·George D Leikauf
Feb 3, 2005·Environmental Health Perspectives·Ana Navas-AcienEliseo Guallar
Feb 19, 2010·Indian Journal of Occupational and Environmental Medicine·Ross G Cooper, Adrian P Harrison
Dec 17, 2011·Journal of Environmental and Public Health·Deborah A KennedyDugald Seely
Jun 10, 2014·Journal of Hazardous Materials·Xuejun GuoJing Zhang
Aug 1, 2014·Journal of Environmental Sciences (China)·Xuejun GuoSisi Li
Jul 22, 2014·Chemosphere·Sudipta RakshitRupali Datta
Jun 2, 2012·TheScientificWorldJournal·Rajmund MichalskiAleksandra Łyko
Aug 21, 2014·Environmental Science and Pollution Research International·Sheng-Xiang QuanJia-Mo Fu
Sep 10, 2013·Research in Veterinary Science·D B BentoP R Romão
Jan 10, 2013·Bulletin of Environmental Contamination and Toxicology·S K MandalT K Jana
Jun 12, 2009·Drug and Chemical Toxicology·Joydeep DasParames C Sil
Jan 14, 2016·Chemosphere·Jian-Xin FanDong-Mei Zhou
Apr 11, 2012·International Journal of Hygiene and Environmental Health·P M FélixH T Wolterbeek
Aug 12, 2008·The Science of the Total Environment·Laura Haffert, Dave Craw
Dec 11, 2007·Trends in Biochemical Sciences·Gerd P BienertThomas P Jahn
Mar 10, 2006·Chemico-biological Interactions·Simplice A DzamitikaFrédéric Frézard

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