Arsenic exposure and human papillomavirus response in non-melanoma skin cancer Mexican patients: a pilot study

International Archives of Occupational and Environmental Health
J Alberto Rosales-CastilloEmma S Calderón-Aranda

Abstract

We assessed the relationships between chronic arsenic (As) exposure, human papilloma virus (HPV) contact and non-melanoma skin cancer (NMSC) by means of a dermatology clinic-based case-control study (42 cases and 48 controls) in Region Lagunera, Mexico, where chronic As poisoning is endemic. Exposure was determined through detailed history of residence in the As-contaminated area and measurement of As levels in drinking water and urine. We used a consensus epitope from the central region of L1 protein of the HPV family to determine antibodies against HPV. A history of As exposure and HPV seropositivity were associated with increased NMSC risks. A history of exposure to high levels of As increased the risk for NMSC (OR = 4.53; P = 0.11) in the group of seronegative HPV patients. A positive response to HPV significantly increased the OR for NMSC to 9.04 (P = 0.01) when history showed exposure to low levels of As. Interestingly, the OR was significantly increased to 16.5 (P = 0.001) when both exposure to high levels of As and HPV seropositivity were present. In addition, the presence of NMSC increased the OR (5.45; P = 0.03) for a positive response to HPV when history showed exposure to low levels of As, but the OR was increased t...Continue Reading

Citations

Jul 28, 2007·BMC Public Health·Berta SuárezRoberto Zanetti
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Nov 29, 2011·The Science of the Total Environment·Tyler R McClintockFaruque Parvez
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Aug 5, 2015·Journal of Cutaneous Medicine and Surgery·Michelle PrattWayne Gulliver
May 5, 2006·Environmental and Molecular Mutagenesis·Andrés BendeskyPatricia Ostrosky-Wegman
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Oct 10, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Natalie H MatthewsEunyoung Cho
Nov 20, 2020·The Science of the Total Environment·C Cristina Osuna-MartínezFederico Páez-Osuna

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