Arsenic Exposure Contributes to the Bioenergetic Damage in an Alzheimer's Disease Model

ACS Chemical Neuroscience
Sandra Aurora NiñoSergio Zarazúa

Abstract

Worldwide, every year there is an increase in the number of people exposed to inorganic arsenic (iAs) via drinking water. Human populations present impaired cognitive function as a result of prenatal and childhood iAs exposure, while studies in animal models demonstrate neurobehavioral deficits accompanied by neurotransmitter, protein, and enzyme alterations. Similar impairments have been observed in close association with Alzheimer's disease (AD). In order to determine whether iAs promotes the pathophysiological progress of AD, we used the 3xTgAD mouse model. Mice were exposed to iAs in drinking water from gestation until 6 months (As-3xTgAD group) and compared with control animals without arsenic (3xTgAD group). We investigated the behavior phenotype on a test battery (circadian rhythm, locomotor behavior, Morris water maze, and contextual fear conditioning). Adenosine triphosphate (ATP), reactive oxygen species, lipid peroxidation, and respiration rates of mitochondria were evaluated, antioxidant components were detected by immunoblots, and immunohistochemical studies were performed to reveal AD markers. As-3xTgAD displayed alterations in their circadian rhythm and exhibited longer freezing time and escape latencies compared...Continue Reading

Citations

Nov 22, 2019·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Carla Garza-LombóRodrigo Franco
Jul 28, 2020·Environmental Science and Pollution Research International·Reyaz Hassan MirMubashir Hussain Masoodi
Feb 24, 2021·Environmental Toxicology and Pharmacology·Churaibhon WisessaowapakJutamaad Satayavivad
May 16, 2020·Chemical Research in Toxicology·Lok Ming Tam, Yinsheng Wang
Jun 13, 2021·Toxicology Letters·Churaibhon WisessaowapakJutamaad Satayavivad
Sep 18, 2021·Neurotoxicity Research·Sandra A NiñoMaría E Jiménez-Capdeville
Oct 6, 2021·Human & Experimental Toxicology·Macario Martínez-CastilloAraceli Hernández-Zavala
Oct 8, 2021·Environmental Science and Pollution Research International·Rahul TripathiPravir Kumar

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