Arsenic (III, V), indium (III), and gallium (III) toxicity to zebrafish embryos using a high-throughput multi-endpoint in vivo developmental and behavioral assay

Chemosphere
Christopher I OlivaresReyes Sierra-Alvarez

Abstract

Gallium arsenide (GaAs), indium gallium arsenide (InGaAs) and other III/V materials are finding increasing application in microelectronic components. The rising demand for III/V-based products is leading to increasing generation of effluents containing ionic species of gallium, indium, and arsenic. The ecotoxicological hazard potential of these streams is unknown. While the toxicology of arsenic is comprehensive, much less is known about the effects of In(III) and Ga(III). The embryonic zebrafish was evaluated for mortality, developmental abnormalities, and photomotor response (PMR) behavior changes associated with exposure to As(III), As(V), Ga(III), and In(III). The As(III) lowest observable effect level (LOEL) for mortality was 500 μM at 24 and 120 h post fertilization (hpf). As(V) exposure was associated with significant mortality at 63 μM. The Ga(III)-citrate LOEL was 113 μM at 24 and 120 hpf. There was no association of significant mortality over the tested range of In(III)-citrate (56-900 μM) or sodium citrate (213-3400 μM) exposures. Only As(V) resulted in significant developmental abnormalities with LOEL of 500 μM. Removal of the chorion prior to As(III) and As(V) exposure was associated with increased incidence of mor...Continue Reading

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Citations

Apr 26, 2017·Environmental Toxicology and Chemistry·Andrew BarrickCatherine Mouneyrac
Mar 12, 2017·International Journal of Molecular Sciences·Ram Manohar BasnetMaurizio Memo
Feb 1, 2017·Journal of Applied Toxicology : JAT·Yoshifumi HorieNorihisa Tatarazako
May 19, 2017·Zebrafish·Douglas W ToddAbraham Jacob
Jul 5, 2017·Nanoscale·Rafael Ceña-DiezMªÁngeles Muñoz-Fernández
Oct 27, 2018·Toxicological Sciences : an Official Journal of the Society of Toxicology·Katharina DachPamela J Lein
Jan 24, 2019·Journal of Applied Toxicology : JAT·Remy Babich, Rebecca J Van Beneden
Jul 20, 2018·Bulletin of Environmental Contamination and Toxicology·Yoshifumi HorieNorihisa Tatarazako
Nov 29, 2017·Journal of Applied Toxicology : JAT·Yoshifumi HorieNorihisa Tatarazako
Feb 15, 2020·Chemosphere·Yasmine KouhailBrian Berkowitz
Dec 17, 2020·International Journal of Molecular Sciences·Ignacio Relaño-Rodríguez, Maria Ángeles Muñoz-Fernández
Jan 28, 2019·Analytica Chimica Acta·Elise RotureauJosé Paulo Pinheiro
Jun 29, 2021·Environmental Pollution·Jason A CoralMaria Bondesson

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