Arsenic intoxication, a hemorheologic view

Clinical Hemorheology and Microcirculation
A BolliniM Rasia

Abstract

Arsenic (As) is a toxic semi-metal of wide distribution in nature. People living in regions where drinking water contains large quantities of arsenic, have an unusually high likelihood of developing blood-vessel diseases, but little is known about the mechanisms involved, i.e. the blood rheologic alterations that would contribute to the circulatory obstruction. Erythrocytes are the main target cells for arsenic compounds systemically absorbed and their cell membrane is the first place against the toxic. In this paper we have examined the in vitro effect of arsenic (As(V)) on the rheologic properties of human erythrocytes in relation with membrane fluidity and internal microviscosity. According to our present results, As(V) treatment produces oxidative degradation of membrane lipids and alteration of internal microviscosity. These red blood cells (RBCs) membrane and cytoplasmic structural damage consequently alters RBCs rheologic properties: an alteration of the RBCs discoid shape to stomatocytes, a diminution of erythrocyte deformability and an enhancement of osmotic fragility and cell aggregability. These effects impaired blood fluid behaviour that contribute to obstruct peripheral circulation and provides anemia, both clinic ...Continue Reading

Citations

Jul 13, 2014·Clinical Hemorheology and Microcirculation·G HernándezG Bazzoni
Oct 28, 2016·Journal of Basic and Clinical Physiology and Pharmacology·Rubia MondalPrabir Kr Mukhopadhyay
Dec 30, 2014·American Journal of Hematology·Julien PerrinJean-François Lesesve
Sep 1, 2017·Journal of Applied Toxicology : JAT·Sergio Ulhoa Dani, Gerhard Franz Walter
Oct 6, 2021·Human & Experimental Toxicology·Macario Martínez-CastilloAraceli Hernández-Zavala

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