Arsenic Metabolites and Methylation Capacity Among Individuals Living in a Rural Area with Endemic Arseniasis in Inner Mongolia, China

Biological Trace Element Research
Binggan WeiNa Cui

Abstract

More than 0.3 million individuals are subject to chronic exposure to arsenic via their drinking water in Inner Mongolia, China. To determine arsenic methylation capacity profiles for such individuals, concentrations of urinary arsenic metabolites were measured for 548 subjects using high-performance liquid chromatography and a hydride generator combined with inductively coupled plasma-mass spectrometry. Mean urinary concentrations of dimethylarsonic acid (DMA), monomethylarsonic acid (MMA), inorganic arsenic (iAs), and total arsenic (TAs) were 200.50, 46.71, 52.96, and 300.17 μg/L, respectively. The %iAs, %DMA, and %MMA were 15.98, 69.72, and 14.29 %. Mean urinary %iAs and %MMA were higher in males, while urinary %DMA was higher in females. There was a strong positive correlation between %iAs and %MMA, with negative correlations between %iAs and %DMA, and %iAs and %MMA. In addition, %iAs and %MMA were positively associated with total arsenic in drinking water (WAs), while %DMA was negatively related with WAs. Regression analysis indicated that the primary methylation index (PMI) and secondary methylation index (SMI) generally decreased with increasing WAs. Females had a higher arsenic methylation capacity compared to males. You...Continue Reading

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Citations

Nov 9, 2016·International Journal of Hygiene and Environmental Health·Xuan ZhangYuxiang Zhu
Feb 11, 2016·International Journal of Environmental Research and Public Health·Hui ShenMingxia Jing
Feb 10, 2018·International Journal of Environmental Research and Public Health·Fabrizio MinichilliElisa Bustaffa
Jun 28, 2018·Environmental Science and Pollution Research International·Binggan WeiKegong Wu
Jul 24, 2020·International Journal of Environmental Research and Public Health·Elisa BustaffaFabrizio Minichilli
Jun 28, 2018·Environmental Geochemistry and Health·Binggan WeiKegong Wu
Dec 3, 2020·Toxicology and Applied Pharmacology·Hiroshi Yamauchi, Ayako Takata
Jul 13, 2021·Reviews on Environmental Health·Christiana KarachaliouIoannis Kalavrouziotis

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