Arsenic methylation patterns before and after changing from high to lower concentrations of arsenic in drinking water

Environmental Health Perspectives
C Hopenhayn-RichA H Smith

Abstract

Inorganic arsenic (In-As), an occupational and environmental human carcinogen, undergoes biomethylation to monomethylarsonate (MMA) and dimethylarsinate (DMA). It has been proposed that saturation of methylation capacity at high exposure levels may lead to a threshold for the carcinogenicity of In-As. The relative distribution of urinary In-As, MMA, and DMA is used as a measure of human methylation capacity. The most common pathway for elevated environmental exposure to In-As worldwide is through drinking water. We conducted a biomarker study in northern Chile of a population chronically exposed to water naturally contaminated with high arsenic content (600 micrograms/l). In this paper we present the results of a prospective follow-up of 73 exposed individuals, who were provided with water of lower arsenic content (45 micrograms/l) for 2 months. The proportions of In-As, MMA, and DMA in urine were compared before and after intervention, and the effect of other factors on the distribution of arsenic metabolites was also analyzed. The findings of this study indicate that the decrease in arsenic exposure was associated with a small decrease in the percent In-As in urine (from 17.8% to 14.6%) and in the MMA/DMA ratio (from 0.23 to ...Continue Reading

References

Sep 15, 1979·Toxicology and Applied Pharmacology·G K TamE Sandi
Aug 1, 1977·Environmental Health Perspectives·E A Crecelius
Jul 1, 1992·Environmental Health Perspectives·A H SmithM T Smith
Mar 1, 1992·American Journal of Epidemiology·M N BatesC Hopenhayn-Rich
Jan 1, 1991·Bulletin of Environmental Contamination and Toxicology·L R Johnson, J G Farmer
Feb 20, 1988·Lancet·C J ChenM M Wu
Aug 1, 1988·Clinical Biochemistry·R Weinshilboum
Aug 15, 1988·Biochemical Pharmacology·J P Buchet, R Lauwerys
Oct 1, 1986·The Science of the Total Environment·M Vahter, B Lind
Jan 1, 1981·International Archives of Occupational and Environmental Health·J P BuchetH Roels
Apr 1, 1994·Environmental Health Perspectives·H Carlson-LynchP D Boardman
Jul 1, 1995·Environmental Health Perspectives·P Mushak, A F Crocetti
Feb 1, 1995·Environmental Research·D J HewittH F Simmons
Oct 1, 1993·American Industrial Hygiene Association Journal·M F BoenigerJ Rosenberg
Jun 1, 1996·Environmental Health Perspectives·C Hopenhayn-RichL E Moore

❮ Previous
Next ❯

Citations

Nov 21, 2013·Archives of Environmental Contamination and Toxicology·Imar Mansilla-RiveraCarlos J Rodríguez-Sierra
Jun 1, 2002·Microbiology and Molecular Biology Reviews : MMBR·Ronald Bentley, Thomas G Chasteen
Dec 4, 2003·Environmental Health Perspectives·Claudia HopenhaynDavid Kalman
Jun 10, 2011·Environmental Health Perspectives·Arin BasuAllan H Smith
Jan 17, 2013·Journal of Exposure Science & Environmental Epidemiology·Margaret Kurzius-SpencerJefferey L Burgess
Jan 17, 2013·Environmental Health Perspectives·Maria Tellez-PlazaAna Navas-Acien
Mar 14, 2013·International Journal of Environmental Research and Public Health·Saika NizamTamie Nakajima
Mar 15, 2003·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Chiho WatanabeRyutaro Ohtsuka
Dec 17, 2008·Analytical and Bioanalytical Chemistry·Carl P VerdonRobert L Jones
Nov 12, 2013·Environmental Toxicology and Pharmacology·Elyssa R GelmannKathleen M McCarty
May 8, 2013·Environmental Science and Pollution Research International·Xin LiGuifan Sun
Feb 25, 2009·Critical Reviews in Toxicology·Ulrike Schuhmacher-WolzKlaus Schneider
Jan 24, 2013·International Journal of Hygiene and Environmental Health·Pritha BhattacharjeeAshok K Giri
Nov 29, 2011·The Science of the Total Environment·Tyler R McClintockFaruque Parvez
Sep 21, 2010·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Mahfoud MessarahAbdelfattah El Feki
Apr 17, 2007·The Science of the Total Environment·Prosun BhattacharyaG Panaullah
Nov 4, 2006·The Science of the Total Environment·Manonmanii KrishnamohanJack C Ng
May 2, 2003·Annals of the New York Academy of Sciences·Lee E MooreRichard B Hayes
Jan 9, 1999·Environmental and Molecular Mutagenesis·J Mäki-PaakkanenJ Pekkanen
Jul 22, 2011·International Journal of Environmental Research and Public Health·Jianwei GaoLinsheng Yang
Oct 24, 2007·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Shoko OshikawaDipankar Chakraborti
Oct 24, 2007·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·Abul Hasnat MiltonS M Shahidullah
Dec 5, 2000·Environmental Health Perspectives·V J Brown
Dec 5, 2000·Environmental Health Perspectives·A H Smith, C M Steinmaus
Dec 5, 2000·Environmental Health Perspectives·C Varga
Jul 23, 2013·Environmental Health Perspectives·Diane Gilbert-DiamondMargaret R Karagas
May 20, 2004·Journal of Exposure Analysis and Environmental Epidemiology·Yoshihisa FujinoUNKNOWN Japan Inner Mongolia Arsenic Pollution Study Group
Jan 11, 2007·Journal of Environmental Monitoring : JEM·Eid I BrimaParvez I Haris
Feb 28, 2013·Journal of Exposure Science & Environmental Epidemiology·Xi ShuhuaSun Guifan
Jun 5, 2008·Journal of Exposure Science & Environmental Epidemiology·Kathleen L CaldwellJohn D Osterloh
Mar 17, 2007·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Chin-Hsiao Tseng
Nov 7, 2019·Environmental Health : a Global Access Science Source·Shangzhi GaoDavid Chistopher Christiani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.