Arsenic release from glass containers by action of intravenous nutrition formulation constituents

International Journal of Pharmaceutics
Denise BohrerMarieli da Silva Marques

Abstract

Pharmacopoeias prescribe tests to determine the levels of arsenic in raw materials and glass containers. In this study, glass ampoules for injectables containing individually the main components of intravenous nutrition formulations were submitted to the hydrolytic resistance test by heating at 121 degrees C for 30 min. As(V) and As(III) levels in these solutions after heating were determined by hydride generation atomic absorption spectrometry. The arsenic content of substances used in these formulations was previously determined, as well as the arsenic content of the glass containers. The results showed that raw substances as well as glass containers contain arsenic. Moreover, arsenic is released during the heating (hydrolytic resistance test). However, the amount released and the arsenic species present in solution depend on the solution composition. While As(V) was the predominant specie in glass, solutions containing reducing substances such as glucose and vitamins had As(III) in higher concentration. Therefore, arsenic is released from glass containers during the heating for sterilization, and reacts with formulation constituents depending on their reducing properties.

References

Dec 1, 1995·Clinical Biochemistry·F Y Leung
Jul 27, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·M M Pluhator-MurtonL M Gramlich
Jan 15, 2002·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·D BohrerS C Pomblum
Feb 18, 2005·JPEN. Journal of Parenteral and Enteral Nutrition·Denise BohrerMorgana Dessuy

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Citations

Aug 22, 2015·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Nikolaos A KazakisGeorge Kitis
Dec 10, 2013·The Science of the Total Environment·Elena SturchioGiuseppe Macino
Sep 16, 2017·Journal of Food and Drug Analysis·Xianghui Li, Pingping Qian

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