PMID: 2484518Jan 1, 1988Paper

Arsenic, selenium, and zinc in patients with Blackfoot disease

Biological Trace Element Research
S M Lin, M H Yang

Abstract

Blackfoot disease is a peripheral vascular disease resulting in gangrene of the lower extremities. Extensive epidemiological study implicates that high arsenic content in artesian well water is the responsible causal factor of the disease. In the present study the concentrations of arsenic, selenium, and zinc in the body fluids and hair of patients with Blackfoot disease, in comparison to age- and sex-matched normal controls, are investigated. Two analytical techniques that include atomic absorption spectrometry and neutron activation analysis were used for the analysis of urine, serum, hair, and whole blood. The analytical results indicate that hair arsenic of the patients is significantly higher than that of the controls, but still below the critical value of 1 microgram/g. In addition, the patients showed significantly lower concentrations of Se and Zn in the urine and blood than the normal controls. The possible connection of these elements with the etiology of the disease is discussed.

References

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Citations

Jan 1, 1996·International Archives of Occupational and Environmental Health·D M ByrdS Lai
Nov 1, 1993·Biological Trace Element Research·T C PanC W Huang
Jun 1, 1995·Biological Trace Element Research·T H Lin, Y L Huang
Sep 13, 2012·Current Atherosclerosis Reports·Katherine MoonAna Navas-Acien
Sep 14, 2011·Journal of Toxicology·Eman M Alissa, Gordon A Ferns
Feb 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Yu ChenHabibul Ahsan
May 7, 2002·The Journal of Dermatology·Hsin-Su YuGwo-Shing Chen
Feb 15, 2016·Current Environmental Health Reports·Daniele FerrarioThomas Hartung
Jun 19, 2015·Environmental Toxicology and Chemistry·Wenhong FanNan Zhang
May 28, 2004·Toxicology and Applied Pharmacology·Chin-Hsiao Tseng
Nov 22, 2007·Clinica Chimica Acta; International Journal of Clinical Chemistry·Zhi HuangXinrong Zhang
Apr 17, 2007·Toxicology and Applied Pharmacology·Chih-Hao WangChien-Jen Chen
Oct 24, 2007·Journal of Environmental Science and Health. Part A, Toxic/hazardous Substances & Environmental Engineering·George C D Adamson, David A Polya
May 6, 2006·Environmental Health Perspectives·Ana Navas-AcienEliseo Guallar
Nov 5, 2005·American Journal of Epidemiology·Ana Navas-AcienEliseo Guallar
Oct 7, 2006·The American Journal of Clinical Nutrition·Gemma Flores-MateoEliseo Guallar
Aug 11, 2021·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Narayanan GopiBaskaralingam Vaseeharan

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