Arsenic speciation and identification of monomethylarsonous acid and monomethylthioarsonic acid in a complex matrix

Analytical Chemistry
Santha Ketavarapu V YathavakillaJohn T Creed

Abstract

Anion-exchange chromatography was utilized for speciation of arsenite (As(III)), arsenate (As(V)), dimethylarsinic acid (DMA(V)), monomethylarsonic acid (MMA(V)), monomethylarsonous acid (MMA(III)), and the new As species monomethylthioarsonic acid (MMTA), using inductively coupled plasma mass spectrometric (ICPMS) detection. MMA(III) and MMTA were identified for the first time in freeze-dried carrot samples that were collected over 25 years ago as part of a joint U.S. EPA, U.S. FDA, and USDA study on trace elements in agricultural crops. The discovery of MMA(III) and MMTA in terrestrial foods necessitated the analytical characterization of synthetic standards of both species, which were used for standard addition in carrot extracts. The negative ion mode, high-resolution electrospray mass spectrometry (HR-ESI-MS) data produced molecular ions of m/z 122.9418 and 154.9152 for MMA(III) and MMTA, respectively. However, ESI-MS was not sensitive enough to directly identify MMA(III) and MMTA in the carrot extracts. Therefore, to further substantiate the identification of MMA(III) and MMTA, two additional separations using an Ion-120 column were developed using the more sensitive ICPMS detection. The first separation used 20 mM tetram...Continue Reading

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Citations

Jul 20, 2012·Archives of Toxicology·Takayuki Watanabe, Seishiro Hirano
Nov 4, 2008·Analytical and Bioanalytical Chemistry·Katarzyna WrobelJoseph A Caruso
Nov 28, 2013·Journal of Agricultural and Food Chemistry·Marta CalatayudDinoraz Vélez
Nov 3, 2012·Chemical Research in Toxicology·Marta CalatayudDinoraz Vélez
Jul 7, 2010·Environmental Health Perspectives·Tom Van de WieleKaren Bradham
Feb 22, 2011·Journal of Hazardous Materials·Yarong LiRose Amal
Apr 7, 2010·Chemosphere·Yarong LiRose Amal
Sep 10, 2011·Biomedical Chromatography : BMC·Pradeep AlavaTom Van de Wiele
Apr 2, 2014·Mass Spectrometry Reviews·Eric HandbergHuanwen Chen
Jul 28, 2016·Chemical Research in Toxicology·Baowei ChenX Chris Le
May 17, 2014·Environmental Health Perspectives·Sergio S C D C RubinTom Van de Wiele

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