Arsenic toxicity and epimutagenecity: the new LINEage

Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine
Somnath PaulPritha Bhattacharjee

Abstract

Global methylation pattern regulates the normal functioning of a cell. Research have shown arsenic alter these methylation landscapes within the genome leading to aberrant gene expression and inducts various pathophysiological outcomes. Long interspersed nuclear elements (LINE-1) normally remains inert due to heavy methylation of it's promoters, time and various environmental insults, they lose these methylation signatures and begin retro-transposition that has been associated with genomic instability and cancerous outcomes. Of the various high throughput technologies available to detect global methylation profile, development of LINE-1 methylation index shall provide a cost effect-screening tool to detect epimutagenic events in the wake of toxic exposure in a large number of individuals. In the present review, we tried to discuss the state of research and whether LINE-1 methylation can be considered as a potent epigenetic signature for arsenic toxicity.

References

Jun 15, 1997·Nucleic Acids Research·Z Xiong, P W Laird
Oct 6, 1997·Proceedings of the National Academy of Sciences of the United States of America·C Q ZhaoM P Waalkes
Jul 26, 2002·Proceedings of the National Academy of Sciences of the United States of America·Igor OvchinnikovGary D Swergold
Aug 30, 2002·International Review of Neurobiology·Luke Eckersley
Apr 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Brook BrouhaHaig H Kazazian
Jun 24, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Stuart J MoatJonathan Goodfellow
Dec 15, 2005·International Journal of Cancer. Journal International Du Cancer·Pritha GhoshAshok K Giri
May 8, 2007·The Science of the Total Environment·Koichi OhnoYoshihiko Matsui
Feb 5, 2010·Practical Neurology·Liberty MathewJane E Adcock
Feb 25, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Charlotte S WilhelmCarmen J Marsit
Sep 30, 2010·CNS & Neurological Disorders Drug Targets·Helmar C Lehmann, Ahmet Höke
Feb 10, 2011·Journal of Inherited Metabolic Disease·Emma J FootittPeter T Clayton
Feb 16, 2011·Journal of Applied Toxicology : JAT·K JomovaM Valko
Jun 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Mary Beth TerryRegina M Santella
Mar 3, 2012·Environmental Health Perspectives·Mohammad Bakhtiar HossainKarin Broberg
Apr 3, 2012·Environmental Health Perspectives·Molly L KileDavid C Christiani
May 4, 2012·Environmental Health : a Global Access Science Source·Ponpat IntarasunanontMathuros Ruchirawat
Jul 27, 2012·Epidemiology·Angeliki LambrouJoel Schwartz
Sep 20, 2012·Journal of Exposure Science & Environmental Epidemiology·Somnath PaulAshok K Giri
Mar 19, 2013·Environmental Toxicology and Pharmacology·Hongqi FengDianjun Sun
Apr 5, 2013·Environmental Health Perspectives·Salman M TajuddinUNKNOWN Spanish Bladder Cancer/EPICURO Study Investigators
Jul 23, 2013·Scientific Reports·Mayukh BanerjeeAshok K Giri
Aug 3, 2013·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Somnath PaulAshok K Giri
Jan 18, 2014·Epigenetics : Official Journal of the DNA Methylation Society·Sophie LagetPierre-Antoine Defossez
Feb 6, 2014·Genome Biology·Andrew E Jaffe, Rafael A Irizarry
Apr 3, 2014·Archives of Toxicology·Elisa BustaffaLucia Migliore
Jun 3, 2014·Journal of Experimental & Clinical Cancer Research : CR·Sanjay KumarPaul B Tchounwou

❮ Previous
Next ❯

Citations

Jan 10, 2019·Annual Review of Pharmacology and Toxicology·Qiao Yi ChenMax Costa
Jan 19, 2019·International Journal of Phytoremediation·Patricio PiccoPablo Pacheco
Mar 8, 2020·Environmental and Molecular Mutagenesis·Brunella Del Re, Gianfranco Giorgi
Mar 1, 2019·Environmental Science and Pollution Research International·Ruihui ChenJie Yang
Apr 18, 2021·Biological Trace Element Research·Munir OzturkTomonori Kawano
Jul 8, 2021·Journal of Hazardous Materials·Muneeb U RehmanParvaiz Ahmad

❮ Previous
Next ❯

Methods Mentioned

BETA
immunoprecipitation
Assay
histone acetylation

Software Mentioned

COBRA

Related Concepts

Related Feeds

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.