PMID: 11331436May 2, 2001Paper

Arsenic trioxide: an emerging therapy for multiple myeloma

The Oncologist
N C Munshi

Abstract

Arsenic trioxide can inhibit proliferation and induce apoptosis in multiple myeloma (MM) cells in vitro and in vivo. In addition to affecting tumor growth, arsenic trioxide has been shown to inhibit angiogenesis, suggesting that it may have significant potency in the treatment of MM. Based on these observations, the clinical efficacy of arsenic trioxide was evaluated in patients with advanced refractory MM using a fixed-dose intravenous infusion given daily for a maximum of 60 days. Nine patients were evaluable. All nine had extensive prior therapy; seven had two or more high-dose chemotherapy cycles with autologous stem cell support. All nine patients had cytogenetic abnormalities, and six had chromosome 13 deletions. Of the four patients who completed more than 30 days of arsenic trioxide infusion, two had >50% reduction in myeloma paraprotein, one had stable disease, and one progressed. Of the five patients with <30 days infusion, two had stable disease and three progressed. Thus, on an intent-to-treat basis, two of nine (23%) patients responded (>50% paraprotein reduction). The regimen was well tolerated except for development of cytopenia, which responded to G-CSF, and a grade III pulmonary complication in one patient. In ...Continue Reading

References

Feb 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·W M GregoryJ S Malpas
Feb 1, 1997·Hematology/oncology Clinics of North America·M Attal, J L Harousseau
Jun 30, 1998·Bone Marrow Transplantation·B BarlogieR Alexanian
Feb 26, 1999·Leukemia & Lymphoma·C M ShipmanP I Croucher
Mar 18, 1999·Therapeutic Apheresis : Official Journal of the International Society for Apheresis and the Japanese Society for Apheresis·G A Siami, F S Siami
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Jan 8, 2000·Hematology/oncology Clinics of North America·S V Rajkumar, P R Greipp
Aug 29, 2000·Journal of Cancer Research and Clinical Oncology·J DrachH Huber

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Citations

Aug 7, 2002·Blood Reviews·Joan J RyooKenneth C Anderson
Mar 6, 2003·Reviews in Clinical and Experimental Hematology·Deepak GuptaKenneth C Anderson
Oct 29, 2004·The New England Journal of Medicine·Robert A Kyle, S Vincent Rajkumar
Sep 25, 2003·Cancer Biotherapy & Radiopharmaceuticals·Diely PichardoSteven Rosen
Dec 6, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tatyana A ZykovaZigang Dong
Jul 14, 2010·International Journal of Environmental Research and Public Health·Jacqueline J StevensChristian Rogers
Jan 19, 2005·Anti-cancer Drugs·Jiong HuZhu Chen
Dec 29, 2004·Leukemia & Lymphoma·Markus Thomas RojewskiHubert Schrezenmeier
Apr 4, 2006·Annals of Medicine·Robert A Kyle, S Vincent Rajkumar
Oct 11, 2005·Mayo Clinic Proceedings·S Vincent Rajkumar, Robert A Kyle
May 10, 2006·Journal of the American Academy of Nurse Practitioners·Colleen Dvorak
May 16, 2002·Seminars in Hematology·Zhu ChenSai-Juan Chen
Jul 20, 2005·Best Practice & Research. Clinical Haematology·S Vincent Rajkumar, Robert A Kyle
Feb 26, 2014·Clinical Lymphoma, Myeloma & Leukemia·K Martin KortuemA Keith Stewart
Nov 8, 2003·Clinical Journal of Oncology Nursing·Joseph D Tariman
Feb 6, 2018·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Maneka HoonjanPurvi Bhatt
Nov 14, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Monika LyczkoAleksander Bilewicz
Jan 14, 2003·Hematological Oncology
Mar 13, 2020·Metallomics : Integrated Biometal Science·Qian Qian WangHua Naranmandura
Oct 29, 2003·Cancer Control : Journal of the Moffitt Cancer Center·Mohamad A Hussein

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