Arsenic trioxide and the phosphoinositide 3-kinase/akt pathway in chronic lymphocytic leukemia.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
Dennis J Goussetis, Leonidas C Platanias

Abstract

Simultaneous targeting of the phosphoinositide 3-kinase (PI3K)/Akt pathway increases arsenic trioxide (ATO)-dependent cytotoxicity of chronic lymphocytic leukemia (CLL) cells, whereas it has no significant effects on normal lymphocytes. Combinations of ATO with small molecules that target PI3K and/or Akt may provide a novel approach for the treatment of CLL.

References

May 16, 2002·Seminars in Hematology·Kelly DavisonWilson H Miller
Nov 24, 2006·Molecular Cancer Therapeutics·Patrick YoonLeonidas C Platanias
Dec 1, 2007·The Journal of Biological Chemistry·Jessica K AltmanLeonidas C Platanias
Apr 14, 2009·The Journal of Biological Chemistry·Leonidas C Platanias
Jan 21, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kevin D CourtneyJeffrey A Engelman
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Jun 11, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Javier Redondo-MuñozAngeles García-Pardo

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Citations

May 20, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Hui-Wen ChiuYing-Jan Wang
Mar 29, 2016·Journal of Applied Toxicology : JAT·Juyoung ShimJulie A Gosse
Jan 13, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guangjun JiaoKang Yang
Oct 29, 2013·Neurochemistry International·Meysam YousefiArdeshir Ghavamzadeh
Oct 19, 2017·Molecular Cancer Research : MCR·Jonathan B BellLeonidas C Platanias
Mar 27, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Bahareh ToosiMajid Teremmahi Ardestanii

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