Abstract
To study the role of arsenic trioxide (As(2)O(3)) in regulating peritoneal invasive activity of ovarian carcinoma cells in vitro and in vivo. The effects of As(2)O(3) on human ovarian cancer cell lines (3AO, SW626 and HO-8910PM) migration, invasion and adhesion with tumor cells and human peritoneal mesothelial cells (HPMC) were observed by means of cell migration test, cell invasion test and cell adhesion test. The effects of As(2)O(3) on MMP-2, MMP-9, TIMP-1 and TIMP-2 gene expressions and protein expressions of tumor cells were determined by RT-PCR and ELISA, respectively. In animal experiments, ovarian tumor cells were implanted into abdominal cavity of nude mice and then the nude mice were treated by intraperitoneal injection of different doses As(2)O(3). The foci on the surface of peritoneum were counted. As(2)O(3) inhibited tumor cells migration, invasion and adhesion with HPMC in a dose-dependent manner, while the same treatment enhanced tumor cell-tumor cell interactions. As(2)O(3) inhibited mRNA and protein expressions of MMP-2, MMP-9 and TIMP-2 of tumor cells. In contrast, As(2)O(3) increased mRNA and protein expressions of TIMP-1. As(2)O(3) could reduce tumor cells peritoneal metastasis in nude mice. As(2)O(3) inhibi...Continue Reading
References
Jan 1, 1990·Archives of Toxicology·H KreppelW Forth
Oct 1, 1990·The Journal of Clinical Investigation·S D ShapiroH G Welgus
Feb 1, 1996·Journal of Cellular Biochemistry·M ZafarullahJ P Pelletier
Oct 11, 1996·The Journal of Biological Chemistry·K HammaniY A DeClerck
Nov 5, 1998·The New England Journal of Medicine·R E Gallagher
May 18, 1999·The American Journal of Pathology·K LessanA P Skubitz
Nov 5, 1999·Advances in Cancer Research·A Wells
Mar 10, 2000·Biochemical and Biophysical Research Communications·H Kim, G Koh
May 4, 2000·The American Journal of Pathology·M Y HsuM Herlyn
Aug 10, 2000·Surgery Today·K MizutaniK Shirouzu
Aug 19, 2000·Cellular and Molecular Life Sciences : CMLS·N JohanssonV M Kähäri
Dec 6, 2000·Gynecologic Oncology·B DavidsonA Berner
Feb 15, 2001·Seminars in Cancer Biology·I Stamenkovic
Mar 29, 2001·The Journal of Pathology·M E van RossenC H van Eijck
Apr 27, 2001·Seminars in Cancer Biology·J KassisA Wells
Jun 28, 2001·Oncogene·S ZuckerW T Chen
Mar 14, 2002·International Journal of Molecular Medicine·Zhong-Ying ShenYi Zeng
May 16, 2002·Seminars in Hematology·Kelly DavisonWilson H Miller
Jun 12, 2002·The Journal of Biological Chemistry·Sang-Oh YoonAn-Sik Chung
Nov 20, 2002·World Journal of Gastroenterology : WJG·Yue-Zu FanYao-Qin Yang
Jan 18, 2003·Blood·Qun LiuYair Gazitt
May 14, 2003·The Journal of Biological Chemistry·Yasuyuki HirashimaToshihiko Terao
Nov 9, 2004·Oncogene·Lin-Hung WeiChang-Yao Hsieh
Apr 13, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·R UsluE Goker
Jun 18, 2005·Journal of Cellular Biochemistry·Myung-Jin ParkChang Hun Rhee
Sep 22, 2005·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·B KongQ Yang
Nov 12, 2005·Journal of Biomedical Science·Huei-Sheng HuangCheng-Hsin Chuang
Aug 28, 2007·Experimental Cell Research·Alison A WalzakCaren C Helbing
Feb 19, 2009·International Journal of Surgical Pathology·Shu-Dong YangZhi-Yi Zhou
Citations
Jul 23, 2014·Annals of Surgical Oncology·Yi-Wen ChangJen-Liang Su
Jun 10, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Colin E OlsenScott Boitano
Feb 15, 2012·Toxicological Sciences : an Official Journal of the Society of Toxicology·Clarisse S MuenyiJ Christopher States
Sep 26, 2013·Molecular Cancer Therapeutics·Yilin ZhangErnst Lengyel
Nov 19, 2008·Thyroid : Official Journal of the American Thyroid Association·Eleonore FröhlichRichard Wahl
May 29, 2010·Cell Death and Differentiation·D M SmithM Nanjundan
Sep 26, 2015·Biomolecules·Clarisse S MuenyiJ Christopher States
Mar 29, 2011·The Science of the Total Environment·Shehong LiBaoshan Zheng
Jun 24, 2011·Journal of Ovarian Research·Clarisse S MuenyiJ Christopher States
Apr 15, 2014·Molecular Carcinogenesis·Lu SiZhong Li
Jan 16, 2009·Journal of Ovarian Research·C William Helm, J Christopher States
Dec 20, 2011·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Pei-Shi OngPaul C Ho
Jul 13, 2007·Cancer Treatment Reviews·Pierre J Dilda, Philip J Hogg
Dec 18, 2008·Reproductive Sciences·Victoria L Bae-JumpPaola A Gehrig
Sep 6, 2012·International Journal of Molecular Sciences·Jun XiaZhiwei Wang
Aug 23, 2017·Nanotechnology·Xiaoqin ChiJinhao Gao
Sep 23, 2009·Cancer Science·Ning ZhangWen Di
Nov 19, 2019·Current Cancer Drug Targets·Md WahiduzzamanYoshitaka Hosokawa
Aug 11, 2011·The Journal of Pharmacy and Pharmacology·Yoko HiwatashiToshihiko Hirano
Apr 29, 2015·Transplantation·Chang GaoZhongquan Qi
May 5, 2011·Experimental Biology and Medicine·Yingxia LiuYingmei Zhang
Jul 4, 2012·Oncology Reports·Buchu WuWen Di
Mar 5, 2016·Nanoscale·Fei-yan ChenQun Tang
Jun 4, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Richard W AhnThomas V O'Halloran
Jul 18, 2008·Chemical Research in Toxicology·Tzeon-Jye ChiouChi-Jr Liao
Jun 7, 2021·European Journal of Medicinal Chemistry·Shan WangMeng Zhou