Arsenic trioxide negatively affects Echinococcus granulosus

Antimicrobial Agents and Chemotherapy
Bo WangHailong Lv

Abstract

Spillage of cyst contents during surgery is the major cause of recurrences of hydatidosis, also called cystic echinococcosis (CE). Currently, many scolicidal agents are used for inactivation of the cyst contents. However, due to complications in the use of those agents, new and more-effective treatment options are urgently needed. The aim of this study was to investigate the in vitro efficacy of arsenic trioxide (ATO) against Echinococcus granulosus protoscolices. Protoscolices of E. granulosus were incubated in vitro with 2, 4, 6, and 8 μmol/liter ATO; viability of protoscolices was assessed daily by microscopic observation of movements and 0.1% eosin staining. A small sample from each culture was processed for scanning and transmission electron microscopy. ATO demonstrated a potent ability to kill protoscolices, suggesting that ATO may represent a new strategy in treating hydatid cyst echinococcosis. However, the in vivo efficacy and possible side effects of ATO need to be explored.

References

Mar 27, 1998·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·H BesimA Korkmaz
Sep 30, 1998·The British Journal of Surgery·M SonişikO Hamamci
Dec 5, 1998·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·K ErzurumluK Tac
Jan 1, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·T C ZhangJ F Qin
Jun 27, 2002·Breast Cancer Research and Treatment·Germano BajEnza Ferrero
Nov 29, 2002·Anesthesia and Analgesia·Aline AlbiYves Ozier
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Marianne StettlerAndrew Hemphill
Oct 31, 2003·Toxicologic Pathology·Paul B TchounwouJose A Centeno
Feb 20, 2004·Molecular and Cellular Biochemistry·Paul B TchounwouAnita K Patlolla
Apr 12, 2005·Molecular Interventions·Stanley Scheindlin
Aug 18, 2005·Journal of Gastroenterology and Hepatology·Ibrahim YetimAbdullah Guvenli
Sep 7, 2006·Antimicrobial Agents and Chemotherapy·Arunasalam NaguleswaranAndrew Hemphill
Oct 22, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Pedro Moro, Peter M Schantz
Jan 15, 2009·Toxicology and Industrial Health·A RayS Bhattacharya
Mar 17, 2009·World Journal of Surgery·Omer TopcuAyhan Koyuncu
Jan 30, 2010·Parasitology Research·Mohammad Moazeni, Sara Larki
Mar 7, 2012·Vitamins and Hormones·Elspeth M Beauchamp, Aykut Uren
Apr 2, 2014·International Journal of Surgery·Hossein MahmoudvandSareh Jahanbakhsh
Jul 27, 2014·Toxicology and Applied Pharmacology·Lizbeth López-CarrilloMariano E Cebrian

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Amoebiasis

Amoebiasis, infection by the protozoan parasite Entamoeba histolytica, remains a global health problem, despite the availability of effective treatment. Here is the latest research.

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Related Papers

The Korean Journal of Parasitology
Hailong LvYufeng Jiang
Experimental Parasitology
Mohammad Moazeni, Mohammad-Reza Alipour-Chaharmahali
The Korean Journal of Parasitology
Hossein MahmoudvandMajid Fasihi Harandi
© 2021 Meta ULC. All rights reserved