Arsenite induces testicular oxidative stress in vivo and in vitro leading to ferroptosis

Ecotoxicology and Environmental Safety
Pan MengChengzhi Chen

Abstract

Ferroptosis is a newly identified form of cell death characterized by accumulation of intracellular iron and requirement of lipid peroxidation. However, whether arsenite triggers testicular cell death via ferroptosis remains unclear. In this study, after administrating of adult male mice with 0.5, 5 and 50 mg/L arsenite for six months via drinking water, the results showed that arsenite caused the pathological changes in mouse testis and significantly reduced the number of sperm. Mitochondrial injuries were observed as the major ultrastructural damages induced by arsenite, and these damages were accompanied by the apparent mitochondrial oxidative damage in the testis, manifested by accumulation of iron, production of reactive oxygen species and lipid peroxidation products. We also demonstrated that arsenite significantly activated ferroptosis-related signal pathways in the mouse testis. To further verify the results obtained in the animal model, GC-2spd cells were employed as the in vitro culture system. Consistently, the results revealed arsenite remarkably triggered the ferroptotic cell death in vitro, and inhibition of ferroptosis by ferrostatin-1 could attenuate this adverse effect in cells. These findings together indicate...Continue Reading

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Citations

Aug 18, 2020·Autophagy·Xin ChenDaolin Tang
Aug 19, 2020·Antioxidants & Redox Signaling·Behrouz HassanniaTom Vanden Berghe
Mar 17, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Junting XiaoChengzhi Chen
Mar 25, 2021·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Soudeh Ghafouri-FardMohammad Taheri
Apr 30, 2021·Biochemical Pharmacology·Guangxiang XuLianxiang Luo
Nov 9, 2021·Human & Experimental Toxicology·Fatemeh YarmohammadiGholamreza Karimi

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