Artemether Attenuates the Progression of Non-small Cell Lung Cancer by Inducing Apoptosis, Cell Cycle Arrest and Promoting Cellular Senescence

Biological & Pharmaceutical Bulletin
Jian ChenZhengzhi Wu

Abstract

Lung cancer is the most common cause of cancer death, approximately 85% of which are non-small cell lung cancer (NSCLC). Here we found that artemether (ART), a natural derivative of artemisinin, significantly inhibits the proliferation of NSCLC cells in a dose- and time-dependent manner. We also demonstrated that high concentration of ART induces apoptosis in NSCLC cells through down-regulating the level of anti-apoptotic protein B-cell lymphoma-2 (Bcl-2), cellular inhibitor of apoptosis protein 1 (cIAP1) and cellular inhibitor of apoptosis protein 2 (cIAP2). While low concentration of ART inhibits the mRNA level of cell cycle related genes including cyclin-dependent kinase 1 (CDK1), cyclin-dependent kinase 2 (CDK2), cyclin-dependent kinase 6 (CDK6), cyclin A2, cyclin B1 and cyclin D1, leading to cell cycle arrest in NSCLC cells. Moreover, we confirmed that low concentration of ART induces DNA double-stranded breaks (DSBs), as well as promoting cellular senescence in NSCLC cells by up-regulating the mRNA and protein level of p16. Taken together, ART represents a promising new anti-NSCLC drug candidate that could attenuate progression of NSCLC cells in a p53-independent manner through inducing apoptosis, cell cycle arrest and pr...Continue Reading

References

Jan 23, 2004·The New England Journal of Medicine·Rodrigo ArriagadaUNKNOWN International Adjuvant Lung Cancer Trial Collaborative Group
Mar 29, 2006·Transactions of the Royal Society of Tropical Medicine and Hygiene·Elisabeth Hsu
Aug 11, 2006·Trends in Molecular Medicine·Wynand P Roos, Bernd Kaina
Nov 26, 2008·Nature Reviews. Cancer·Natalie Meyer, Linda Z Penn
Dec 6, 2008·EMBO Reports·Kay E GurleyChristopher J Kemp
Apr 21, 2009·Nature Reviews. Cancer·John L Nitiss
Jan 9, 2010·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Angela Grimes, Sathees B C Chandra
Nov 1, 2011·Seminars in Cancer Biology·Lars-Gunnar Larsson
Nov 6, 2012·Nature Reviews. Immunology·Peter Vandenabeele, Mathieu J M Bertrand
Mar 5, 2014·Cold Spring Harbor Perspectives in Medicine·Amy S Farrell, Rosalie C Sears
May 27, 2014·American Society of Clinical Oncology Educational Book·Heather WakeleeMartin J Edelman
Sep 10, 2014·Sub-cellular Biochemistry·Stephen Bohlman, James J Manfredi
Sep 27, 2015·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Edna OokoThomas Efferth
Nov 28, 2015·Trends in Cell Biology·Lorenzo GalluzziGuido Kroemer
Jan 26, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Lauren Amable
Oct 16, 2016·Journal of Experimental & Clinical Cancer Research : CR·Chengcheng YangSida Qin
May 19, 2017·Cell Death & Disease·Lu XiaoJinbao Liu
May 24, 2017·Proceedings of the National Academy of Sciences of the United States of America·Hui YangZhijian J Chen
Sep 4, 2017·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Wei-Qiang TanBing Jia
Sep 10, 2017·Journal of Experimental & Clinical Cancer Research : CR·Xiaomin FengZhimin He
Nov 17, 2017·Clinical and Experimental Pharmacology & Physiology·Dongsheng ShangZhigang Tu

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Citations

Feb 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Ho-Sung LeeDae-Yeon Lee
Aug 14, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Jingfeng LiuJian Chen

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