PMID: 20647693Jul 22, 2010Paper

Artemisia herba-alba Asso relaxes the rat aorta through activation of NO/cGMP pathway and K(ATP) channels

Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi
Mounia SkikerAbderrahim Ziyyat

Abstract

Artemisia herba-alba Asso (Compositae) is used in oriental Morocco to treat diabetes and arterial hypertension. The present work evaluated the vasorelaxant effect of Artemisia herba-alba aqueous extract (AHAE) in isolated rat aorta and the mechanism underlying this effect. In endothelium-containing aorta preparations, AHAE (10(-3), 10(-2), 10(-1), 1 and 2 mg/mL) relaxed the contraction elicited by noradrenaline in a concentration-dependent manner. This effect is dependent upon integrity of the vascular endothelium as it was fully abolished in endothelium-denuded preparations. The vasorelaxant effect of AHAE (2 mg/mL) was also inhibited by N(G)-nitro-L-arginine methyl-ester (100 microM), methylene blue (10 microM) or 1H-[1,2,4] oxadiazolo [4,3-a] quinoxaline-1-one (50 microM) but not by 10 microM atropine. This effect remained unchanged by tetraethylammonium (5 mM) or indomethacin (10 microM) whereas it was significantly attenuated by glibenclamide (10 microM). These results suggest that AHAE produces an endothelium-dependent relaxation of the isolated rat aorta, an effect that seems mainly mediated through stimulation of the endothelial nitric oxide synthase by mechanisms other than activation of muscarinic receptors. Activatio...Continue Reading

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Citations

Oct 1, 2011·International Journal of Impotence Research·S C KamJ S Hyun
Jun 13, 2013·Pakistan Journal of Biological Sciences : PJBS·Abderrahmane Moufid, Mohamed Eddouks
Mar 26, 2013·Korean journal of urology·Jungmo DoJae Seog Hyun

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