Artemisinin analogue SM934 ameliorates DSS-induced mouse ulcerative colitis via suppressing neutrophils and macrophages

Acta Pharmacologica Sinica
Yu-Xi YanJian-Ping Zuo

Abstract

Ulcerative colitis (UC) is a chronic, nonspecific inflammatory bowel disease (IBD) characterized by complicated and relapsing inflammation in the gastrointestinal tract. SM934 is a water-soluble artemisinin analogue that shows anti-inflammatory and immuno-regulatory effects. In this study, we investigated the effects of SM934 on UC both in vivo and in vitro. A mouse model of colitis was established in mice by oral administration of 5% dextran sulfate sodium (DSS). SM934 (3, 10 mg/kg per day, ig) was administered to the mice for 10 days. After the mice were sacrificed, colons, spleens and mesenteric lymph nodes (MLNs) were collected for analyses. We showed that SM934 administration restored DSS-induced body weight loss, colon shortening, injury and inflammation scores. Furthermore, SM934 administration significantly decreased the disease activity index (DAI), histopathological scores, and myeloperoxidase (MPO) activities in colonic tissues. Moreover, SM934 administration dose-dependently decreased the mRNA and protein levels of DSS-induced pro-inflammatory cytokines (IL-1β, IL-6 and TNF-α), and the percentage of macrophages and neutrophils in colon tissues. The effects of SM934 on LPS-stimulated RAW 264.7 cells and THP-1-derived...Continue Reading

References

Jul 1, 1995·Journal of Gastroenterology and Hepatology·M C GrimmW F Doe
Feb 3, 1999·Annals of the New York Academy of Sciences·M F NeurathK H Büschenfelde
Sep 14, 1999·British Journal of Pharmacology·C B GrahamesP P Humphrey
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
May 6, 2003·Gastroenterology·Luca SantucciAntonio Morelli
Apr 14, 2006·Cancer Treatment and Research·Arndt J Schottelius, Harald Dinter
Jul 27, 2007·Nature·R J Xavier, D K Podolsky
Sep 11, 2007·Advanced Drug Delivery Reviews·Stefan Wirtz, Markus F Neurath
May 16, 2008·Journal of Internal Medicine·I AtreyaM F Neurath
Sep 25, 2010·Nature Reviews. Immunology·Nadine Cerf-Bensussan, Valérie Gaboriau-Routhiau
Feb 15, 2012·Journal of Visualized Experiments : JoVE·Janice J KimWaliul I Khan
Jun 19, 2013·Autoimmunity Reviews·Alessandra GeremiaAntonio Di Sabatino
Feb 11, 2014·Current Protocols in Immunology·Benoit ChassaingMatam Vijay-Kumar
Apr 23, 2014·Nature Reviews. Immunology·Markus F Neurath
May 30, 2014·Clinical and Experimental Gastroenterology·Renée Marchioni Beery, Sunanda Kane
Mar 4, 2015·Nature Reviews. Gastroenterology & Hepatology·Ashwin N Ananthakrishnan

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Citations

Apr 18, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanwei WuWei Tang
May 21, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ke KeYousef Abu-Amer
Nov 19, 2019·Frontiers in Pharmacology·Peeraphong LertnimitphunHongxi Xu
Dec 6, 2020·Antioxidants·Jose D Puentes-PardoJosefa León
Mar 26, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Xiuhong KangShengsheng Zhang
Apr 2, 2021·Journal of Experimental Pharmacology·Monica Baiula, Santi Spampinato
May 21, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Qing QiWei Tang
Jun 21, 2021·Medicinal Research Reviews·Yuqing MengJigang Wang
Jun 20, 2021·Drug Development Research·Huanhuan ZhuMinying Wang
Jul 22, 2021·Medicinal Research Reviews·Thomas Efferth, Franz Oesch

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Methods Mentioned

BETA
ELISA
PMA
flow cytometry
protein assay
electrophoresis
FACS
nuclear translocation

Software Mentioned

FlowJo
GraphPad Prism

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