Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their anti-malarial activities are additive with toxic sphingolipid analogues that block the network.

Molecular and Biochemical Parasitology
T AkompongK Haldar

Abstract

There is great need to identify and characterize drug targets and chemotherapeutic strategies against malaria. Here we show that a vacuolar-network induced by the human malaria parasite Plasmodium falciparum, is a major import pathway for artemisinin, a leading, new anti-malarial that is known to be effective against drug resistant strains. We also show that artemisinin-treatment induces aberrant, budding of a vacuolar-network membrane protein and its antimalarial activity is additive with toxic sphingolipid analogues that block the network. The data suggest that artemisinin alters membrane protein export from the vacuolar-network and combinations with anti-network reagents have the potential to provide powerful new chemotherapy for drug resistant malaria.

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Citations

Dec 26, 2001·Veterinary Parasitology·Jong-Tai KimHee-Jeong Youn
Jun 23, 2010·Antimicrobial Agents and Chemotherapy·Stephanie Gaw ValderramosSanjeev Krishna
Dec 8, 2010·Antimicrobial Agents and Chemotherapy·Sophie PooleyHenry M Staines
Dec 26, 2001·Antimicrobial Agents and Chemotherapy·Nehal VyasChristy M Wyandt
Feb 9, 2016·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·G C BeheraV S Bharati
Jul 26, 2011·Acta Tropica·Sócrates HerreraMyriam Arévalo-Herrera
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Aug 22, 2003·Nature·U Eckstein-LudwigS Krishna
Apr 20, 2002·Current Opinion in Infectious Diseases·R K Haynes
Mar 29, 2001·Physiological Reviews·K Kirk

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