Artemisinin-naphthoquine combination therapy for uncomplicated pediatric malaria: a pharmacokinetic study.

Antimicrobial Agents and Chemotherapy
Kevin T BattyTimothy M E Davis

Abstract

Artemisinin-naphthoquine (ART-NQ) is a coformulated antimalarial therapy marketed as a single-dose treatment in Papua New Guinea and other tropical countries. To build on limited knowledge of the pharmacokinetic properties of the components, especially the tetra-aminoquinoline NQ, we studied ART-NQ disposition in Papua New Guinea children aged 5 to 12 years with uncomplicated malaria, comparing a single dose (15 and 6 mg/kg of body weight) administered with water (group 1; n = 13), a single dose (22 and 9 mg/kg) with milk (group 2) (n = 17), and two daily doses of 22 and 9 mg/kg with water (group 3; n = 16). The plasma NQ concentration was assayed by high-performance liquid chromatography, and the plasma ART concentration was assayed using liquid chromatography-mass spectrometry. Population-based multicompartment pharmacokinetic models for NQ and ART were developed. NQ disposition was best characterized by a three-compartment model with a mean absorption half-life (t(1/2)) of 1.0 h and predicted median maximum plasma concentrations that ranged as high as 57 μg/liter after the second dose in group 3. The mean NQ elimination t(1/2) was 22.8 days; clearance relative to bioavailability (CL/F) was 1.1 liters/h/kg; and volume at stea...Continue Reading

References

Sep 1, 1989·Reviews of Infectious Diseases·P A Mackowiak
Feb 1, 1987·The Journal of Infectious Diseases·N J WhiteE K Njelesani
Jan 1, 1984·European Journal of Clinical Pharmacology·M Frisk-HolmbergB Domeij-Nyberg
Apr 1, 1983·British Journal of Clinical Pharmacology·L L GustafssonF Sjöqvist
Jun 1, 1995·British Journal of Clinical Pharmacology·J C WetsteynC J Van Boxtel
Jan 1, 1996·Transactions of the Royal Society of Tropical Medicine and Hygiene·M Hassan AlinA Björkman
Jan 1, 1996·Annual Review of Nutrition·P G Welling
Jan 1, 1997·European Journal of Clinical Pharmacology·C CrevoisierC Kleinbloesem
May 13, 1998·British Journal of Clinical Pharmacology·J S SidhuL D Cong
May 20, 1998·Clinical Pharmacology and Therapeutics·M AshtonD C Le
May 30, 1998·Biopharmaceutics & Drug Disposition·M AshtonD C Le
Mar 13, 1999·International Journal of Antimicrobial Agents·B BeovicM Marolt-Gomiscek
Apr 9, 1999·Computer Methods and Programs in Biomedicine·E N Jonsson, M O Karlsson
Jan 28, 2004·Acta Tropica·Jing-yan WangBo-an Wu
Mar 5, 2004·British Journal of Clinical Pharmacology·Te-Yu HungDoung Socheat
May 27, 2005·Antimicrobial Agents and Chemotherapy·Ing-Kye SimKenneth F Ilett
Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Joel TarningNicholas J White
Aug 19, 2006·Antimicrobial Agents and Chemotherapy·Andrew CroweTimothy M E Davis
Dec 21, 2006·Antimicrobial Agents and Chemotherapy·Timothy M E DavisKenneth F Ilett
Feb 16, 2007·Tropical Medicine & International Health : TM & IH·Elizabeth A AshleyFrançois Nosten
Mar 17, 2007·Archives of Disease in Childhood·T N Johnson
Oct 5, 2007·Annual Review of Pharmacology and Toxicology·B J Anderson, N H G Holford
Oct 31, 2007·Antimicrobial Agents and Chemotherapy·Harin A KarunajeewaTimothy M E Davis
Jan 16, 2008·Clinical Pharmacokinetics·Polina I German, Francesca T Aweeka
Dec 10, 2008·The New England Journal of Medicine·Harin A KarunajeewaTimothy M E Davis
Jan 21, 2010·Antimicrobial Agents and Chemotherapy·Harin A KarunajeewaTimothy M E Davis
Mar 9, 2010·Nature Reviews. Microbiology·Arjen M DondorpLorenz von Seidlein
Jan 18, 2011·Journal of Pharmaceutical and Biomedical Analysis·E RozetPh Hubert
Feb 9, 2011·The AAPS Journal·Martin BergstrandMats O Karlsson

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Citations

Dec 15, 2015·Expert Review of Clinical Pharmacology·Timothy M E DavisLaurens Manning
Aug 18, 2012·International Journal of Medical Microbiology : IJMM·Florian C SchraderMartin Schlitzer
Aug 12, 2014·Expert Opinion on Pharmacotherapy·Benjamin J VisserMartin P Grobusch
Apr 15, 2016·Drugs·Brioni R MooreTimothy M E Davis
Mar 12, 2015·Drug Metabolism and Pharmacokinetics·Meitong ZangJie Xing
Feb 24, 2015·The Cochrane Database of Systematic Reviews·Rachel IsbaDavid Sinclair
Mar 25, 2015·Antimicrobial Agents and Chemotherapy·Sam SalmanTimothy M E Davis
Jul 25, 2018·Antimicrobial Agents and Chemotherapy·Ali Mohamed AliUNKNOWN WWARN Amodiaquine PK Study Group
Nov 30, 2019·Future Medicinal Chemistry·Ishan WadiAbhinav Sinha
Jan 18, 2020·Cells·Nicole Urban, Michael Schaefer
Aug 26, 2020·Antimicrobial Agents and Chemotherapy·Zhu-Chun BeiJing-Yan Wang
Apr 17, 2013·Bioorganic & Medicinal Chemistry Letters·Marco A BiamonteKarine G Le Roch
Jul 21, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Henglin YangLiwang Cui

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