Arterial baroreflex regulation of muscle sympathetic nerve activity at rest and during stress

The Journal of Physiology
Anthony V IncognitoPhilip J Millar

Abstract

The arterial baroreflex controls vasoconstrictor muscle sympathetic nerve activity (MSNA) in a negative feedback manner by increasing or decreasing activity during spontaneous blood pressure falls or elevations, respectively. Spontaneous sympathetic baroreflex sensitivity is commonly quantified as the slope of the relationship between MSNA burst incidence or strength and beat-to-beat variations in absolute diastolic blood pressure. We assessed the relationships between blood pressure inputs related to beat-to-beat blood pressure change or blood pressure rate-of-change (variables largely independent of absolute pressure) and MSNA at rest and during exercise and mental stress. The number of participants with strong linear relationships between MSNA and beat-to-beat diastolic blood pressure change variables or absolute diastolic blood pressure were similar at rest, although during stress the beat-to-beat diastolic blood pressure change variables were superior. Current methods may not fully characterize the capacity of the arterial baroreflex to regulate MSNA. Spontaneous sympathetic baroreflex sensitivity (sBRS) is commonly quantified as the slope of the relationship between variations in absolute diastolic blood pressure (DBP) an...Continue Reading

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Nov 6, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anthony V IncognitoPhilip J Millar

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Citations

Jun 6, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Massimo NardoneGlen E Foster
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anthony V IncognitoPhilip J Millar
Aug 12, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Takuto HamaokaJian Cui

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