Arterial baroreflex regulation of muscle sympathetic single-unit activity in men: influence of resting blood pressure

American Journal of Physiology. Heart and Circulatory Physiology
Anthony V IncognitoLauro C Vianna

Abstract

The arterial baroreflex has dominant control over multiunit muscle sympathetic nerve activity (MSNA) burst occurrence, but whether this extends to all single units or is influenced by resting blood pressure status is unclear. In 22 men (32 ± 8 yr), we assessed 68 MSNA single units during sequential bolus injections of nitroprusside and phenylephrine (modified Oxford). Sympathetic baroreflex sensitivity (sBRS) was quantified as the weighted negative linear regression slope between diastolic blood pressure (DBP) and single-unit spike firing probability and multiple spike firing. Strong negative linear relationships (r ≥ -0.50) between DBP and spike firing probability were observed in 63/68 (93%) single units (-2.27 ± 1.27%·cardiac cycle-1·mmHg-1 [operating range, 18 ± 8 mmHg]). In contrast, only 45/68 (66%) single units had strong DBP-multiple spike firing relationships (-0.13 ± 0.18 spikes·cardiac cycle-1·mmHg-1 [operating range, 14 ± 7 mmHg]). Participants with higher resting DBP (65 ± 3 vs. 77 ± 3 mmHg, P < 0.001) had similar spike firing probability sBRS (low vs. high, -2.08 ± 1.08 vs. -2.46 ± 1.42%·cardiac cycle-1·mmHg-1, P = 0.33), but a smaller sBRS operating range (20 ± 6 vs. 16 ± 9 mmHg, P = 0.01; 86 ± 24 vs. 52 ± 25% of...Continue Reading

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Nov 6, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Anthony V IncognitoPhilip J Millar

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Citations

Apr 5, 2020·The Journal of Physiology·Anthony V Incognito, Philip J Millar
Aug 29, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Anthony V IncognitoPhilip J Millar
Sep 3, 2020·Journal of Neurophysiology·Jeann L Sabino-CarvalhoLauro C Vianna
Jan 12, 2021·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Massimo NardonePhilip J Millar
Jul 22, 2021·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Massimo NardonePhilip J Millar

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