PMID: 9426030Jan 13, 1998Paper

Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology

Journal of the American College of Cardiology
G SangiorgiR S Schwartz

Abstract

This study was designed to evaluate whether calcium deposition in the coronary arteries is related to atherosclerotic plaque burden and narrowing of the arterial lumen. Many studies have recently documented the feasibility of electron beam computed tomography to detect and quantify coronary artery calcification in patients. Although these studies suggest a general relation between calcification and severity of coronary artery disease, the value of coronary calcium in defining atherosclerotic plaque and coronary lumen narrowing is unclear. Previous pathologic comparisons have failed to detail such a relation in identical histologic sections. This finding may be due to atherosclerotic remodeling. A total of 37 nondecalcified coronary arteries were processed, sectioned at 3-mm intervals (723 sections) and evaluated by computer planimetry and densitometry. A significant relation between calcium area and plaque area was found on a per-heart basis (n = 13, r = 0.87, p < 0.0001), per-artery basis (left anterior descending coronary artery [LAD]: n = 13, r = 0.89, p < 0.0001; left circumflex coronary artery [LCx]: n = 11, r = 0.7, p < 0.001; right coronary artery [RCA]: n = 13, r = 0.89, p < 0.0001) and per-segment basis (n = 723, r = 0...Continue Reading

References

Oct 15, 1992·The American Journal of Cardiology·M GoelJ M Tobis
Oct 1, 1992·Australian and New Zealand Journal of Medicine·P Sleight
Dec 14, 1991·BMJ : British Medical Journal·G Rose
Oct 1, 1991·Journal of the American College of Cardiology·M NobuyoshiK Kimura
Sep 21, 1991·BMJ : British Medical Journal·J T Hobbs
Mar 15, 1990·Journal of the American College of Cardiology·A S AgatstonR Detrano
Jul 1, 1988·Journal of the American College of Cardiology·J A AmbroseV Fuster
May 28, 1987·The New England Journal of Medicine·S GlagovG J Kolettis
Sep 1, 1970·The American Journal of Cardiology·R J FrinkR O Brandenburg
Nov 1, 1965·The American Journal of Roentgenology, Radium Therapy, and Nuclear Medicine·J JorgensR R Kundel
May 1, 1995·Radiology·T M Doherty, R C Detrano
Oct 1, 1994·The Journal of Clinical Investigation·L A FitzpatrickR T Ingram
Jul 1, 1994·Coronary Artery Disease·A Shaknovich
Apr 1, 1993·The Journal of Clinical Investigation·K BoströmL L Demer
Feb 1, 1996·Journal of the American College of Cardiology·R DetranoJ Reed
Jun 1, 1997·Journal of the American College of Cardiology·J A RumbergerR S Schwartz

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Citations

Nov 20, 2010·Neuroradiology·Nu Rhee HongSang-Il Suh
Jan 22, 2010·Heart and Vessels·Kohichiro IwasakiMasanobu Samukawa
Jul 31, 2013·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Yunpeng ShangTadayuki Yakushiji
May 27, 2005·The International Journal of Cardiovascular Imaging·Paul SchoenhagenRichard D White
May 27, 2005·The International Journal of Cardiovascular Imaging·Brad H Thompson, William Stanford
Dec 13, 2006·The International Journal of Cardiovascular Imaging·Alexander BeckerAndreas Knez
Apr 8, 2004·Current Atherosclerosis Reports·Stephan Achenbach, Werner G Daniel
Mar 17, 2004·Current Atherosclerosis Reports·Paolo Raggi, George James
Dec 20, 2012·Current Cardiology Reports·George YoussefMatthew J Budoff
Dec 2, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Matthew J Budoff, Yalcin Hacioglu
Aug 27, 2013·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Alan RozanskiSeth Uretsky
May 10, 2005·The American Journal of Cardiology·Nico R MolletPim J de Feyter
Apr 13, 2005·Atherosclerosis·Allen TaylorPaolo Raggi
Aug 3, 2005·International Journal of Cardiology·Matthew A AllisonC Michael Wright
Dec 12, 2003·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Manuel D Cerqueira, Maria P Rumsey
Feb 1, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Paolo Raggi, Daniel S Berman
Dec 14, 2005·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Stephan Achenbach
Jun 9, 2007·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·John HoNina Radford
Jun 27, 2000·The American Journal of Cardiology·M J BudoffB H Brundage
Mar 7, 2002·The American Journal of Cardiology·Holger P Salazar, Paolo Raggi
Jul 20, 2002·The American Journal of Cardiology·Shenghan LaiJoao A C Lima
Sep 25, 2003·Progress in Cardiovascular Diseases·John A Rumberger
Sep 25, 2003·Progress in Cardiovascular Diseases·Matthew J Budoff
Sep 6, 2003·International Journal of Cardiology·Matthew A AllisonJonathan Tiefenbrun
May 23, 2001·Ultrasound in Medicine & Biology·K J HuntG Heiss
Dec 29, 2000·Journal of the American College of Cardiology·H M ColhounJ H Fuller
May 10, 2001·Journal of the American College of Cardiology·H S Hecht, H R Superko
Mar 26, 2003·Journal of the American College of Cardiology·Julie Anne HoffGeorge T Kondos

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