Arterial calcification in race horses

Veterinary Pathology
L G ArroyoL Viel

Abstract

Calcification of large arteries has been sporadically reported in horses. The pathogenesis is still unknown, but recent studies in humans suggest that this is a regulated biomineralizing process. This study surveyed the prevalence, distribution, and severity of vascular calcification in Thoroughbred and Standardbred racehorses. Histopathologic, ultrastructural imaging, and energy dispersive X-ray elemental analyses were used to examine the lesions. Calcification of the tunica media, predominantly the pulmonary artery, was found in 82% of horses (83/101). Young adult horses (mean [SD] age in years, 4.44 +/- 2.17) of both breeds and sexes were similarly affected. Lesions appeared as white-to-yellowish, hard, and gritty plaques of variable size. On microscopic examination, elastic fibers within the tunica media were thinned, fragmented, and calcified, and surrounded by dense collagen matrix. Elemental analysis showed distinct peaks for calcium and phosphorus, consistent with hydroxyapatite mineral. The frequent occurrence of calcification in the tunica media of large pulmonary arteries of young racing horses indicates the need to investigate its pathogenesis and potential clinical implications.

References

Jul 1, 1989·Journal of Comparative Pathology·K ImaizumiM Kaneko
Jul 1, 1983·Equine Veterinary Journal·J J Cranley
Apr 1, 1993·The Journal of Clinical Investigation·K BoströmL L Demer
Jul 28, 2001·The American Journal of Cardiology·K Boström
Dec 18, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·C R DhoreM J Daemen
Jan 31, 2003·Acta Neuropathologica·Maria Teresa Mandara
Apr 23, 2004·American Journal of Physiology. Endocrinology and Metabolism·Radhika Vattikuti, Dwight A Towler
May 25, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Moeen AbedinLinda L Demer
Dec 21, 2004·American Journal of Hypertension·Ernesto L Schiffrin
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Susan J ZiemanDavid A Kass
May 25, 2005·Atherosclerosis·Yuri V Bobryshev
Jan 21, 2006·Seminars in Dialysis·Ulver Derici, A Meguid El Nahas
Aug 22, 2006·Journal of Internal Medicine·V P IyemereC M Shanahan
Nov 1, 2006·Advances in Cardiology·Rachel H MackeyKim Sutton-Tyrrell
Nov 11, 2006·Circulation Research·Rebecca C JohnsonJoseph Loscalzo
Jan 4, 2007·The Journal of Pathology·S E Greenwald
Mar 22, 2007·Seminars in Dialysis·Rukshana C Shroff, Catherine M Shanahan
Mar 22, 2007·Seminars in Dialysis·Christopher W McIntyre
Mar 30, 2007·Vascular Medicine·Matthew A AllisonC Michael Wright
Aug 8, 2007·Journal of Vascular Surgery·Raul J Guzman
Jan 10, 2008·Archives of Pathology & Laboratory Medicine·Robert G MichelettiMichael C Fishbein

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Citations

Jun 30, 2010·Journal of Veterinary Internal Medicine·P W Physick-Sheard, M K J McGurrin
Feb 26, 2016·Cell Biochemistry and Function·H G TsangV E MacRae
Apr 7, 2017·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Josepha DeLay
Feb 4, 2010·Equine Veterinary Journal·M G TeeterR J Runciman
Feb 22, 2018·American Journal of Veterinary Research·Fe Ter WoortLaurent Viel
Feb 12, 2017·Journal of Applied Physiology·Gonçalo Teixeira de Almeida SilvaLuis G Arroyo
May 8, 2020·Materials·Sylwia OrzechowskaWłodzimierz Lewandowski

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Methods Mentioned

BETA
X-ray
light microscopy

Software Mentioned

SAS
SIS Item
Quartz PCI

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